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Mchr1 Gene Detail
Summary
  • Symbol
    Mchr1
  • Name
    melanin-concentrating hormone receptor 1
  • Synonyms
    Gpr24, Gpr24-9, Mch1r, MCH-1R, melanin-concentrating hormone receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180756
    NCBI Gene: 207911
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81119700-81123165 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180756
 protein coding gene Chr15:81119700-81123165 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022108
 protein coding gene Chr15:81644844-81649721 (+)
A/J MGP_AJ_G0022069
 protein coding gene Chr15:78781026-78784480 (+)
AKR/J MGP_AKRJ_G0022044
 protein coding gene Chr15:80976099-80979544 (+)
BALB/cJ MGP_BALBcJ_G0022075
 protein coding gene Chr15:78805440-78808885 (+)
C3H/HeJ MGP_C3HHeJ_G0021846
 protein coding gene Chr15:80967935-80972390 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022518
 protein coding gene Chr15:84840387-84843978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020048
 protein coding gene Chr15:75252911-75256327 (+)
CAST/EiJ MGP_CASTEiJ_G0021367
 protein coding gene Chr15:81719107-81722541 (+)
CBA/J MGP_CBAJ_G0021811
 protein coding gene Chr15:87497898-87501345 (+)
DBA/2J MGP_DBA2J_G0021940
 protein coding gene Chr15:78265169-78268617 (+)
FVB/NJ MGP_FVBNJ_G0021918
 protein coding gene Chr15:77304148-77307580 (+)
LP/J MGP_LPJ_G0022008
 protein coding gene Chr15:81804602-81808056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021938
 protein coding gene Chr15:92475694-92479165 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022532
 protein coding gene Chr15:81040508-81043968 (+)
PWK/PhJ MGP_PWKPhJ_G0021109
 protein coding gene Chr15:78289335-78292761 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020946
 protein coding gene Chr15:80829499-80832942 (+)
WSB/EiJ MGP_WSBEiJ_G0021419
 protein coding gene Chr15:81445851-81449819 (+)



Homology
more
  • Human Ortholog
    MCHR1, melanin concentrating hormone receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCHR1, melanin concentrating hormone receptor 1
  • Synonyms
    GPR24, MCH-1R, MCH1R, SLC-1, SLC1
  • Links
    NCBI Gene ID: 2847
    neXtProt AC: NX_Q99705
    UniProt: Q99705

  • Chr Location
    22q13.2; chr22:40679273-40682812 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MCHR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 8 alleles in 7 genetic backgrounds
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for some alleles may display osteoporosis, resistance to diet-induced obesity, abnormal pyramidal neuron physiology, hyperactivity, polyphagia, increased heart rate and body temperature, sleep behavior, and impaired conditioned learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    55
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 207911 NCBI Gene Model | MGI Sequence Detail 3466 C57BL/6J ±  kb
    transcript NM_145132 RefSeq | MGI Sequence Detail 2205 C57BL/6  
    polypeptide Q8JZL2 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146183
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 11
      Phenotypes 55
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:343215 Wang M, et al., Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein. Front Endocrinol (Lausanne). 2022;13:848728
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory