Oas1h MGI Mouse Gene Detail - MGI:2180853 - 2'-5' oligoadenylate synthetase 1H

Symbol

Oas1h
Name

2'-5' oligoadenylate synthetase 1H

Feature Type

protein coding gene
IDs

MGI:2180853
NCBI Gene: 246729
Alliance

gene page

Sequence Map

Chr5:120999485-121011569 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.64 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

430 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180853	protein coding gene	Chr5:120999484-121011569 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030018	protein coding gene	Chr5:124283668-124294259 (+)
A/J	MGP_AJ_G0029982	protein coding gene	Chr5:119121079-119139960 (+)
AKR/J	MGP_AKRJ_G0029920	protein coding gene	Chr5:122975460-123034557 (+)
BALB/cJ	MGP_BALBcJ_G0029993	protein coding gene	Chr5:120529647-120541714 (+)
C3H/HeJ	MGP_C3HHeJ_G0029713	protein coding gene	Chr5:123546189-123558033 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030448	protein coding gene	Chr5:128967511-128978278 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0029121	protein coding gene	Chr5:122715160-122728744 (+)
CBA/J	MGP_CBAJ_G0029681	protein coding gene	Chr5:134003060-134056062 (+)
DBA/2J	MGP_DBA2J_G0029831	protein coding gene	Chr5:119221469-119232194 (+)
FVB/NJ	MGP_FVBNJ_G0029787	protein coding gene	Chr5:118160370-118171646 (+)
LP/J	MGP_LPJ_G0029919	protein coding gene	Chr5:124753211-124763889 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029817	protein coding gene	Chr5:137937652-137999043 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030489	protein coding gene	Chr5:122548007-122558673 (+)
PWK/PhJ	MGP_PWKPhJ_G0028834	protein coding gene	Chr5:117997569-118004439 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028673	protein coding gene	Chr5:120271361-120277341 (+)
WSB/EiJ	MGP_WSBEiJ_G0029196	protein coding gene	Chr5:123152502-123163782 (+)

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1
Synonyms

E18/E16, IFI-4, IMD100, OIAS, OIASI
Links

HGNC:8086

NCBI Gene ID: 4938

neXtProt AC: NX_P00973

UniProt: P00973
Chr Location

12q24.13; chr12:112905856-112933219 (+) GRCh38

MGI Vertebrate Homology

Oas1h stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OAS1
Gene Tree

Oas1h

Diseases

1 with human OAS1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Oas1h
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a null allele exhibit normal fertility.

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All GO Annotations

40
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

17
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS19629.1, CCDS51636.1

Ensembl

ENSMUSG00000001168 (Evidence)
NCBI Gene

246729

			Length	Strain/Species	Flank
genomic	246729	NCBI Gene Model \| MGI Sequence Detail	12085	C57BL/6J	± kb
transcript	NM_145228	RefSeq \| MGI Sequence Detail	1708	ZRU/MplStud
polypeptide	NP_660263	RefSeq \| MGI Sequence Detail	369	ZRU/MplStud

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UniProt

2 Sequences
InterPro Domains

IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain

IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal

IPR043519 Nucleotidyltransferase superfamily

IPR002934 Polymerase, nucleotidyl transferase domain

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All nucleic 10

Genomic 1

cDNA 8

Primer pair 1

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:348425 Pham AH, et al., Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024;13(10):802

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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