Nup155 MGI Mouse Gene Detail - MGI:2181182

Symbol

Nup155
Name

nucleoporin 155
Synonyms

D930027M19Rik, mKIAA0791

Feature Type

protein coding gene
IDs

MGI:2181182
NCBI Gene: 170762
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:8138757-8190731 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 3.82 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

1655 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181182	protein coding gene	Chr15:8135861-8190731 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021704	protein coding gene	Chr15:5148007-5201480 (+)
A/J	MGP_AJ_G0021665	protein coding gene	Chr15:5023888-5074740 (+)
AKR/J	MGP_AKRJ_G0021643	protein coding gene	Chr15:5053541-5110082 (+)
BALB/cJ	MGP_BALBcJ_G0021672	protein coding gene	Chr15:4932664-4983337 (+)
C3H/HeJ	MGP_C3HHeJ_G0021448	protein coding gene	Chr15:5105647-5156997 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022111	protein coding gene	Chr15:5340134-5393635 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019648	protein coding gene	Chr15:4598667-4649126 (+)
CAST/EiJ	MGP_CASTEiJ_G0020964	protein coding gene	Chr15:5075429-5131605 (+)
CBA/J	MGP_CBAJ_G0021417	protein coding gene	Chr15:5461206-5516437 (+)
DBA/2J	MGP_DBA2J_G0021541	protein coding gene	Chr15:4944634-4994920 (+)
FVB/NJ	MGP_FVBNJ_G0021519	protein coding gene	Chr15:4864382-4915712 (+)
LP/J	MGP_LPJ_G0021609	protein coding gene	Chr15:5077999-5128532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021544	protein coding gene	Chr15:5679120-5732427 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022134	protein coding gene	Chr15:5096153-5152106 (+)
PWK/PhJ	MGP_PWKPhJ_G0020707	protein coding gene	Chr15:4943918-4995668 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020545	protein coding gene	Chr15:4974519-5032169 (+)
WSB/EiJ	MGP_WSBEiJ_G0021020	protein coding gene	Chr15:5042377-5094146 (+)

Human Ortholog

NUP155, nucleoporin 155

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP155, nucleoporin 155
Synonyms

ATFB15, N155
Links

HGNC:8063

NCBI Gene ID: 9631

neXtProt AC: NX_O75694

UniProt: O75694
Chr Location

5p13.2; chr5:37288137-37371106 (-) GRCh38

MGI Vertebrate Homology

Nup155 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP155
Gene Tree

Nup155

Diseases

1 with human NUP155 associations

				Human Disease	Mouse Models
				familial atrial fibrillation IDs familial atrial fibrillation DOID:0050650 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

14
Targeted

2
Transposon induced

1
Genomic Mutations

1 involving Nup155
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a gene trap allele die prior to E8.5 while heterozygotes develop atrial fibrillation with shortened action potential duration. Homozygotes for a knock-out allele show complete embryonic lethality prior to organogenesis with failure of blastocysts to hatch from the zona pellucida and form in vitro outgrowths.

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All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup155

ZFIN nup155

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All Sequences

62
RefSeq

3
UniProt

10
CCDS

CCDS37034.1

Ensembl

ENSMUSG00000022142 (Evidence)
NCBI Gene

170762

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022142	Ensembl Gene Model \| MGI Sequence Detail	51975	C57BL/6J	± kb
transcript	ENSMUST00000163765	Ensembl \| MGI Sequence Detail	7832	Not Applicable
polypeptide	ENSMUSP00000128819	Ensembl \| MGI Sequence Detail	1391	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011509 nuclear pore complex protein Nup155

(term hierarchy)
InterPro Domains

IPR007187 Nucleoporin, Nup133/Nup155-like, C-terminal

IPR014908 Nucleoporin, Nup133/Nup155-like, N-terminal

IPR004870 Nucleoporin, Nup155-like

IPR042533 Nucleoporin, Nup155-like, C-terminal, subdomain 1

IPR042537 Nucleoporin, Nup155-like, C-terminal, subdomain 2

IPR042538 Nucleoporin, Nup155-like, C-terminal, subdomain 3

IPR036322 WD40-repeat-containing domain superfamily
GlyGen

Q99P88 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 17

Microarray probesets 5

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MGI:2444890

Summaries

All 42

Gene Ontology 11

Phenotypes 12
Earliest

J:314757 Radu A, et al., Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA. J Cell Biol. 1993 Apr;121(1):1-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nup155:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130582	Chr15:8138780-8138791 (+)	29 bp
Tssr130583	Chr15:8138806-8138840 (+)	66 bp
Tssr130584	Chr15:8138851-8138858 (+)	98 bp
Tssr130585	Chr15:8138861-8138870 (+)	109 bp
Tssr130586	Chr15:8142146-8142149 (+)	3,391 bp
Tssr130587	Chr15:8143152-8143163 (+)	4,401 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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