About   Help   FAQ
Prokr2 Gene Detail
Summary
  • Symbol
    Prokr2
  • Name
    prokineticin receptor 2
  • Synonyms
    B830005M06Rik, EG-VEGRF2, Gpcr73l1, Gpr73l1, PKR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181363
    NCBI Gene: 246313
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132211625-132227413 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    570 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181363
 protein coding gene Chr2:132179653-132227413 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026542
 protein coding gene Chr2:135912212-135965077 (-)
A/J MGP_AJ_G0026506
 protein coding gene Chr2:130385529-130433225 (-)
AKR/J MGP_AKRJ_G0026480
 protein coding gene Chr2:134145269-134197742 (-)
BALB/cJ MGP_BALBcJ_G0026518
 protein coding gene Chr2:130786323-130835913 (-)
C3H/HeJ MGP_C3HHeJ_G0026261
 protein coding gene Chr2:134596896-134645402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026963
 protein coding gene Chr2:140043790-140096561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024340
 protein coding gene Chr2:125101765-125149856 (-)
CAST/EiJ MGP_CASTEiJ_G0025722
 protein coding gene Chr2:134908456-134960309 (-)
CBA/J MGP_CBAJ_G0026241
 protein coding gene Chr2:145313462-145368627 (-)
DBA/2J MGP_DBA2J_G0026375
 protein coding gene Chr2:129775817-129826329 (-)
FVB/NJ MGP_FVBNJ_G0026339
 protein coding gene Chr2:128405457-128453878 (-)
LP/J MGP_LPJ_G0026479
 protein coding gene Chr2:136133185-136185211 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026359
 protein coding gene Chr2:149067122-149120871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027018
 protein coding gene Chr2:134111453-134163145 (-)
PWK/PhJ MGP_PWKPhJ_G0025458
 protein coding gene Chr2:129372416-129419987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025260
 protein coding gene Chr2:133267508-133318870 (-)
WSB/EiJ MGP_WSBEiJ_G0025796
 protein coding gene Chr2:135037943-135085732 (-)



Homology
more
  • Human Ortholog
    PROKR2, prokineticin receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROKR2, prokineticin receptor 2
  • Synonyms
    dJ680N4.3, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2
  • Links
    NCBI Gene ID: 128674
    neXtProt AC: NX_Q8NFJ6
    UniProt: Q8NFJ6

  • Chr Location
    20p12.3; chr20:5299218-5316954 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PROKR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    73
  • cDNA Data
    12
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246313 NCBI Gene Model | MGI Sequence Detail 15789 C57BL/6J ±  kb
    transcript NM_144944 RefSeq | MGI Sequence Detail 4533 C57BL/6  
    polypeptide Q8K458 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 15
      Primer pair 6
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2441861
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 26
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346780 Amato E Jr, et al., Illuminating the terminal nerve: Uncovering the link between GnRH-1 neuron and olfactory development. J Comp Neurol. 2024 Mar;532(3):e25599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory