Capn8 MGI Mouse Gene Detail - MGI:2181366

Symbol

Capn8
Name

calpain 8
Synonyms

nCL-2, nCL-2'

Feature Type

protein coding gene
IDs

MGI:2181366
NCBI Gene: 170725
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:182392572-182459917 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 85.37 cM, cytoband H4
Mapping Data

1 experiment

SNPs within 2kb

2097 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181366	protein coding gene	Chr1:182392314-182462021 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016896	protein coding gene	Chr1:189212552-189286506 (+)
A/J	MGP_AJ_G0016875	protein coding gene	Chr1:181490269-181558799 (+)
AKR/J	MGP_AKRJ_G0016840	protein coding gene	Chr1:186874335-186944802 (+)
BALB/cJ	MGP_BALBcJ_G0016833	protein coding gene	Chr1:182123985-182196685 (+)
C3H/HeJ	MGP_C3HHeJ_G0016657	protein coding gene	Chr1:187688053-187759410 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017296	protein coding gene	Chr1:195301203-195376383 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015003	protein coding gene	Chr1:172561225-172628265 (+)
CAST/EiJ	MGP_CASTEiJ_G0016239	protein coding gene	Chr1:187041415-187115317 (+)
CBA/J	MGP_CBAJ_G0016631	protein coding gene	Chr1:202550735-202624697 (+)
DBA/2J	MGP_DBA2J_G0016737	protein coding gene	Chr1:180273204-180343365 (+)
FVB/NJ	MGP_FVBNJ_G0016733	protein coding gene	Chr1:178401584-178469839 (+)
LP/J	MGP_LPJ_G0016812	protein coding gene	Chr1:190392414-190466558 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016765	protein coding gene	Chr1:209551359-209632755 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017333	protein coding gene	Chr1:186694983-186776366 (+)
PWK/PhJ	MGP_PWKPhJ_G0016027	protein coding gene	Chr1:179457771-179532587 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015803	protein coding gene	Chr1:185652704-185727138 (+)
WSB/EiJ	MGP_WSBEiJ_G0016302	protein coding gene	Chr1:186890041-186969731 (+)

Human Ortholog

CAPN8, calpain 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPN8, calpain 8
Synonyms

nCL-2
Links

HGNC:1485

NCBI Gene ID: 388743

neXtProt AC: NX_A6NHC0

UniProt: A6NHC0
Chr Location

1q41

MGI Vertebrate Homology

Capn8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAPN8
Gene Tree

Capn8

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Targeted

12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele or allele that produces a proteolytically inactive protein exhibit increased sensitivity to ethanol-induced gastric mucosa injury.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

7
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAPN8

Xenbase capn8, capn8.3

ZFIN capn8

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All Sequences

49
RefSeq

10
UniProt

3
CCDS

CCDS35814.1, CCDS48477.1

Ensembl

ENSMUSG00000038599 (Evidence)
NCBI Gene

170725

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038599	Ensembl Gene Model \| MGI Sequence Detail	67346	C57BL/6J	± kb
transcript	ENSMUST00000048941	Ensembl \| MGI Sequence Detail	2406	Not Applicable
polypeptide	ENSMUSP00000047164	Ensembl \| MGI Sequence Detail	703	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005020 calpain-8

(term hierarchy)
EC

3.4.22.53
InterPro Domains

IPR050420 Calpain

IPR036213 Calpain large subunit, domain III superfamily

IPR033883 Calpain subdomain III

IPR000169 Cysteine peptidase, cysteine active site

IPR011992 EF-hand domain pair

IPR038765 Papain-like cysteine peptidase superfamily

IPR001300 Peptidase C2, calpain, catalytic domain

IPR022683 Peptidase C2, calpain, domain III

IPR022684 Peptidase C2, calpain family

IPR022682 Peptidase C2, calpain, large subunit, domain III

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All nucleic 4

cDNA 4

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:75402 Hata S, et al., Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. J Mol Evol. 2001 Sep;53(3):191-203
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Capn8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10565	Chr1:182392559-182392575 (+)	-5 bp
Tssr331	Chr1:182392577-182392586 (+)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24