Ggn MGI Mouse Gene Detail - MGI:2181461

Symbol

Ggn
Name

gametogenetin
Synonyms

GGN1, GGN2, GGN3

Feature Type

protein coding gene
IDs

MGI:2181461
NCBI Gene: 243897
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:28869635-28873363 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM
Mapping Data

1 experiment

SNPs within 2kb

107 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181461	protein coding gene	Chr7:28869635-28873401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031974	protein coding gene	Chr7:28077608-28081327 (+)
A/J	MGP_AJ_G0031952	protein coding gene	Chr7:27334660-27338365 (+)
AKR/J	MGP_AKRJ_G0031884	protein coding gene	Chr7:28035931-28039644 (+)
BALB/cJ	MGP_BALBcJ_G0031959	protein coding gene	Chr7:27502555-27506260 (+)
C3H/HeJ	MGP_C3HHeJ_G0031678	protein coding gene	Chr7:28441764-28445477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032423	protein coding gene	Chr7:28964673-28968386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029475	protein coding gene	Chr7:28395163-28398853 (+)
CAST/EiJ	MGP_CASTEiJ_G0031013	protein coding gene	Chr7:21742494-21746213 (+)
CBA/J	MGP_CBAJ_G0031644	protein coding gene	Chr7:30315354-30319067 (+)
DBA/2J	MGP_DBA2J_G0031796	protein coding gene	Chr7:27074316-27078029 (+)
FVB/NJ	MGP_FVBNJ_G0031753	protein coding gene	Chr7:27171535-27175240 (+)
LP/J	MGP_LPJ_G0031876	protein coding gene	Chr7:28368871-28372584 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031789	protein coding gene	Chr7:29694277-29697990 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032453	protein coding gene	Chr7:27529520-27533233 (+)
PWK/PhJ	MGP_PWKPhJ_G0030738	protein coding gene	Chr7:22120056-22123775 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030571	protein coding gene	Chr7:18551612-18555337 (+)
WSB/EiJ	MGP_WSBEiJ_G0031122	protein coding gene	Chr7:27897710-27901429 (+)

Human Ortholog

GGN, gametogenetin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GGN, gametogenetin
Links

HGNC:18869

NCBI Gene ID: 199720

neXtProt AC: NX_Q86UU5

UniProt: Q86UU5
Chr Location

19q13.2; chr19:38384267-38388384 (-) GRCh38

MGI Vertebrate Homology

Ggn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GGN
Gene Tree

Ggn

Diseases

1 with human GGN associations

				Human Disease	Mouse Models
				spermatogenic failure 69 IDs spermatogenic failure 69 DOID:0070568 OMIM:619826

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for this allele exhibit impaired double-strand break repair in spermatocytes.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

10
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

52
RefSeq

11
UniProt

4
CCDS

CCDS21067.1, CCDS52168.1, CCDS90196.1

Ensembl

ENSMUSG00000031493 (Evidence)
NCBI Gene

243897

			Length	Strain/Species	Flank
genomic	243897	NCBI Gene Model \| MGI Sequence Detail	3729	C57BL/6J	± kb
transcript	NM_182694	RefSeq \| MGI Sequence Detail	2653	C57BL/6
polypeptide	Q80WJ1	UniProt \| EBI \| MGI Sequence Detail	673	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007958 gametogenetin

(term hierarchy)
InterPro Domains

IPR031400 Gametogenetin

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

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MGI:2142005

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 1
Earliest

J:84438 Lu B, et al., Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. J Biol Chem. 2003 May 2;278(18):16289-96
Latest

J:278492 Guo K, et al., Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. J Cell Mol Med. 2018 Oct;22(10):4863-4874

TSS for Ggn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65602	Chr7:28867818-28867827 (+)	-1,812 bp
Tssr65603	Chr7:28869629-28869649 (+)	4 bp
Tssr65604	Chr7:28869665-28869674 (+)	35 bp
Tssr65605	Chr7:28869745-28869752 (+)	114 bp
Tssr65606	Chr7:28869770-28869839 (+)	170 bp
Tssr65607	Chr7:28870276-28870285 (+)	646 bp
Tssr65608	Chr7:28870829-28870852 (+)	1,206 bp
Tssr65609	Chr7:28871764-28871771 (+)	2,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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