About   Help   FAQ
Tox Gene Detail
Summary
  • Symbol
    Tox
  • Name
    thymocyte selection-associated high mobility group box
  • Synonyms
    1700007F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181659
    NCBI Gene: 252838
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:6686353-6991557 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 3.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7868 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181659
 protein coding gene Chr4:6686353-6991557 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028037
 protein coding gene Chr4:3204614-3525456 (-)
A/J MGP_AJ_G0027995
 protein coding gene Chr4:3219496-3534081 (-)
AKR/J MGP_AKRJ_G0027961
 protein coding gene Chr4:3210944-3517083 (-)
BALB/cJ MGP_BALBcJ_G0028007
 protein coding gene Chr4:3176300-3496111 (-)
C3H/HeJ MGP_C3HHeJ_G0027737
 protein coding gene Chr4:3351905-3665978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028450
 protein coding gene Chr4:3464565-3788927 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025794
 protein coding gene Chr4:2948639-3252507 (-)
CAST/EiJ MGP_CASTEiJ_G0027191
 protein coding gene Chr4:3209724-3544229 (-)
CBA/J MGP_CBAJ_G0027712
 protein coding gene Chr4:3461038-3785074 (-)
DBA/2J MGP_DBA2J_G0027852
 protein coding gene Chr4:3179584-3492950 (-)
FVB/NJ MGP_FVBNJ_G0027819
 protein coding gene Chr4:3072564-3379930 (-)
LP/J MGP_LPJ_G0027963
 protein coding gene Chr4:3267974-3580954 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027852
 protein coding gene Chr4:3684907-4009954 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028509
 protein coding gene Chr4:3200228-3510376 (-)
PWK/PhJ MGP_PWKPhJ_G0026912
 protein coding gene Chr4:3214822-3527144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026742
 protein coding gene Chr4:3149513-3481443 (-)
WSB/EiJ MGP_WSBEiJ_G0027270
 protein coding gene Chr4:3301697-3610614 (-)



Homology
more
  • Human Ortholog
    TOX, thymocyte selection associated high mobility group box
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOX, thymocyte selection associated high mobility group box
  • Synonyms
    TOX1
  • Links
    NCBI Gene ID: 9760
    neXtProt AC: NX_O94900
    UniProt: O94900

  • Chr Location
    8q12.1; chr8:58805412-59119147 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1168
  • Tissues
    152
  • cDNA Data
    20
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252838 NCBI Gene Model | MGI Sequence Detail 305205 C57BL/6J ±  kb
    transcript NM_145711 RefSeq | MGI Sequence Detail 3998 C57BL/6  
    polypeptide Q66JW3 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016555 thymocyte selection-associated high mobility group box protein TOX
      (term hierarchy)
    • PDB
      2CO9
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR051365 TOX high mobility group box domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923819
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 20
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354290 Bao K, et al., TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma. Nat Commun. 2024 Sep 8;15(1):7850
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory