Hook2 MGI Mouse Gene Detail - MGI:2181664 - hook microtubule tethering protein 2

Symbol

Hook2
Name

hook microtubule tethering protein 2
Synonyms

A630054I03Rik

Feature Type

protein coding gene
IDs

MGI:2181664
NCBI Gene: 170833
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:85717232-85729978 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.44 cM
Mapping Data

3 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181664	protein coding gene	Chr8:85715402-85729981 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033885	protein coding gene	Chr8:85934631-85947994 (+)
A/J	MGP_AJ_G0033868	protein coding gene	Chr8:82538310-82550590 (+)
AKR/J	MGP_AKRJ_G0033794	protein coding gene	Chr8:84983805-85005006 (+)
BALB/cJ	MGP_BALBcJ_G0033861	protein coding gene	Chr8:82670027-82686268 (+)
C3H/HeJ	MGP_C3HHeJ_G0033571	protein coding gene	Chr8:85608952-85621609 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034381	protein coding gene	Chr8:89220405-89235219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031322	protein coding gene	Chr8:76337155-76351842 (+)
CAST/EiJ	MGP_CASTEiJ_G0032901	protein coding gene	Chr8:85040759-85055763 (+)
CBA/J	MGP_CBAJ_G0033547	protein coding gene	Chr8:92236968-92258412 (+)
DBA/2J	MGP_DBA2J_G0033700	protein coding gene	Chr8:82178107-82190613 (+)
FVB/NJ	MGP_FVBNJ_G0033648	protein coding gene	Chr8:81132368-81148783 (+)
LP/J	MGP_LPJ_G0033792	protein coding gene	Chr8:86037593-86050001 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033690	protein coding gene	Chr8:94812662-94827329 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034398	protein coding gene	Chr8:84973254-84989861 (+)
PWK/PhJ	MGP_PWKPhJ_G0032605	protein coding gene	Chr8:81425199-81438409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032441	protein coding gene	Chr8:83783611-83799211 (+)
WSB/EiJ	MGP_WSBEiJ_G0033014	protein coding gene	Chr8:85405955-85418178 (+)

Human Ortholog

HOOK2, hook microtubule tethering protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOOK2, hook microtubule tethering protein 2
Synonyms

HK2
Links

HGNC:19885

NCBI Gene ID: 29911

neXtProt AC: NX_Q96ED9

UniProt: Q96ED9
Chr Location

19p13.13; chr19:12763003-12872740 (-) GRCh38

MGI Vertebrate Homology

Hook2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOOK2
Gene Tree

Hook2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Hook2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

22
cDNA Data

68
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hook2

ZFIN hook2

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All Sequences

100
RefSeq

50
UniProt

5
CCDS

CCDS22489.1, CCDS90430.1

Ensembl

ENSMUSG00000052566 (Evidence)
NCBI Gene

170833

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052566	Ensembl Gene Model \| MGI Sequence Detail	12747	C57BL/6J	± kb
transcript	ENSMUST00000064495	Ensembl \| MGI Sequence Detail	2580	Not Applicable
polypeptide	ENSMUSP00000067752	Ensembl \| MGI Sequence Detail	716	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008683 protein Hook homolog 2

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR008636 Hook, C-terminal

IPR043936 HOOK, N-terminal

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All nucleic 68

cDNA 68

Microarray probesets 3

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MGI:2442857

Summaries

All 71

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 39
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hook2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78505	Chr8:85717214-85717278 (+)	14 bp
Tssr78506	Chr8:85722569-85722602 (+)	5,354 bp
Tssr78507	Chr8:85722609-85722610 (+)	5,378 bp
Tssr78508	Chr8:85722612-85722614 (+)	5,381 bp
Tssr78509	Chr8:85724477-85724487 (+)	7,250 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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