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Ackr4 Gene Detail
Summary
  • Symbol
    Ackr4
  • Name
    atypical chemokine receptor 4
  • Synonyms
    A630091E18Rik, CCBP2, CCR11, Ccrl1, CCX-CKR, PPR1, VSHK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181676
    NCBI Gene: 252837
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:103974881-104003842 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.47 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    893 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181676
 protein coding gene Chr9:103961356-104004132 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035206
 protein coding gene Chr9:105733770-105780729 (-)
A/J MGP_AJ_G0035186
 protein coding gene Chr9:101936363-101979608 (-)
AKR/J MGP_AKRJ_G0035118
 protein coding gene Chr9:104464207-104510029 (-)
BALB/cJ MGP_BALBcJ_G0035179
 protein coding gene Chr9:101649270-101692953 (-)
C3H/HeJ MGP_C3HHeJ_G0034889
 protein coding gene Chr9:104845933-104890453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035699
 protein coding gene Chr9:108659360-108708109 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032597
 protein coding gene Chr9:99506389-99547402 (-)
CAST/EiJ MGP_CASTEiJ_G0034201
 protein coding gene Chr9:104723677-104771601 (-)
CBA/J MGP_CBAJ_G0034858
 protein coding gene Chr9:112439131-112492165 (-)
DBA/2J MGP_DBA2J_G0035019
 protein coding gene Chr9:101418304-101461882 (-)
FVB/NJ MGP_FVBNJ_G0034967
 protein coding gene Chr9:100222817-100266411 (-)
LP/J MGP_LPJ_G0035095
 protein coding gene Chr9:105937413-105985839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035006
 protein coding gene Chr9:114211892-114262154 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035721
 protein coding gene Chr9:104699823-104744842 (-)
PWK/PhJ MGP_PWKPhJ_G0033908
 protein coding gene Chr9:101704016-101748227 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033743
 protein coding gene Chr9:104782907-104801675 (-)
WSB/EiJ MGP_WSBEiJ_G0034321
 protein coding gene Chr9:104581451-104629564 (-)



Homology
more
  • Human Ortholog
    ACKR4, atypical chemokine receptor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACKR4, atypical chemokine receptor 4
  • Synonyms
    CCBP2, CC-CKR-11, CCR10, CCR-11, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
  • Links
    NCBI Gene ID: 51554
    neXtProt AC: NX_Q9NPB9
    UniProt: Q9NPB9

  • Chr Location
    3q22.1; chr3:132597270-132618967 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    116
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252837 NCBI Gene Model | MGI Sequence Detail 28962 C57BL/6J ±  kb
    transcript NM_145700 RefSeq | MGI Sequence Detail 2109 C57BL/6  
    polypeptide Q924I3 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441698
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:78206 Dorf ME, et al., Astrocytes express functional chemokine receptors. J Neuroimmunol. 2000 Nov 1;111(1-2):109-21
    • Latest
      J:338927 Melgrati S, et al., GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity. Front Immunol. 2023;14:1242531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory