Gin1 Gene Detail

Summary

• Symbol
  Gin1
• Name
  gypsy retrotransposon integrase 1
• Synonyms
  4930429M06, 4930429M06Rik, Zh2c2

• Feature Type
  protein coding gene
• IDs
  MGI:2182036
  NCBI Gene: 252876
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr1:97697897-97721434 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 47.76 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  727 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182036	protein coding gene	Chr1:97697894-97721435 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016360	protein coding gene	Chr1:99547762-99570117 (+)
A/J	MGP_AJ_G0016344	protein coding gene	Chr1:96057605-96080354 (+)
AKR/J	MGP_AKRJ_G0016304	protein coding gene	Chr1:98835968-98859033 (+)
BALB/cJ	MGP_BALBcJ_G0016300	protein coding gene	Chr1:96218410-96239581 (+)
C3H/HeJ	MGP_C3HHeJ_G0016127	protein coding gene	Chr1:99133892-99154410 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016759	protein coding gene	Chr1:103490030-103517279 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014477	protein coding gene	Chr1:90331740-90351038 (+)
CAST/EiJ	MGP_CASTEiJ_G0015709	protein coding gene	Chr1:98252170-98275536 (+)
CBA/J	MGP_CBAJ_G0016100	protein coding gene	Chr1:106877615-106906390 (+)
DBA/2J	MGP_DBA2J_G0016205	protein coding gene	Chr1:95266373-95287625 (+)
FVB/NJ	MGP_FVBNJ_G0016206	protein coding gene	Chr1:94260099-94283751 (+)
LP/J	MGP_LPJ_G0016279	protein coding gene	Chr1:100834146-100858660 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016232	protein coding gene	Chr1:110605579-110630153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016798	protein coding gene	Chr1:98845939-98872398 (+)
PWK/PhJ	MGP_PWKPhJ_G0015497	protein coding gene	Chr1:94452125-94474717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015281	protein coding gene	Chr1:97684645-97706124 (+)
WSB/EiJ	MGP_WSBEiJ_G0015772	protein coding gene	Chr1:98681474-98708134 (+)

Homology

• Human Ortholog
  GIN1, gypsy retrotransposon integrase 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GIN1, gypsy retrotransposon integrase 1
  
• Synonyms
  GIN-1, TGIN1, ZH2C2
• Links
  HGNC:25959

  NCBI Gene ID: 54826

  neXtProt AC: NX_Q9NXP7

  UniProt: Q9NXP7

  
  
• Chr Location
  5q21.1; chr5:103086000-103120138 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gin1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: GIN1
• Gene Tree
  Gin1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  19
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  15
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  2 involving Gin1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  38 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  31

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  58
• RefSeq
  10
• UniProt
  3
• CCDS
  CCDS35679.1, CCDS78662.1

• Ensembl
  ENSMUSG00000026333 (Evidence)
• NCBI Gene
  252876

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000026333	Ensembl Gene Model | MGI Sequence Detail	23538	C57BL/6J
transcript	ENSMUST00000112844	Ensembl | MGI Sequence Detail	2046	Not Applicable
polypeptide	ENSMUSP00000108464	Ensembl | MGI Sequence Detail	518	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000007981 gypsy retrotransposon integrase-like protein 1
  (term hierarchy)
• InterPro Domains
  IPR052160 Gypsy Retrotransposon Integrase-like
  IPR001584 Integrase, catalytic core
  IPR041588 Integrase zinc-binding domain
  IPR012337 Ribonuclease H-like superfamily
  IPR036397 Ribonuclease H superfamily

Molecular
Reagents

• All nucleic 31

  cDNA 31

  
  

  Microarray probesets 6

References

• Summaries
  All 33

  Gene Ontology 1

  Phenotypes 13
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8231	Chr1:97697883-97697934 (+)	12 bp
Tssr8232	Chr1:97697950-97697961 (+)	59 bp