Carf MGI Mouse Gene Detail - MGI:2182269

Symbol

Carf
Name

calcium response factor
Synonyms

Als2cr8

Feature Type

protein coding gene
IDs

MGI:2182269
NCBI Gene: 241066
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:60137406-60193112 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 30.45 cM
Mapping Data

1 experiment

SNPs within 2kb

1496 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182269	protein coding gene	Chr1:60137380-60193112 (+)
129S1/SvImJ	ENSMUSG00200018118	protein coding gene	Chr1:57646881-57692750 (+)
A/J	ENSMUSG00195027281	protein coding gene	Chr1:57186162-57232035 (+)
AKR/J	ENSMUSG00220037425	protein coding gene	Chr1:57269240-57315317 (+)
BALB/cJ	ENSMUSG00180013265	protein coding gene	Chr1:57419279-57465367 (+)
C3H/HeJ	ENSMUSG00175000978	protein coding gene	Chr1:57563543-57609413 (+)
C57BL/6NJ	ENSMUSG00215029024	protein coding gene	Chr1:57495432-57541307 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014186	protein coding gene	Chr1:54221585-54277769 (+)
CAST/EiJ	ENSTCUG00005013218	protein coding gene	Chr1:57348767-57397931 (+)
CBA/J	ENSMUSG00210032187	protein coding gene	Chr1:57248501-57295096 (+)
DBA/2J	ENSMUSG00185039156	protein coding gene	Chr1:58368259-58414131 (+)
FVB/NJ	ENSMUSG00205013217	protein coding gene	Chr1:57209358-57255228 (+)
JF1/MsJ	ENSUMUG00000041582	protein coding gene	Chr1:57352532-57399607 (+)
LP/J	ENSMUSG00230024010	protein coding gene	Chr1:58368761-58414629 (+)
NOD/ShiLtJ	ENSMUSG00190024698	protein coding gene	Chr1:57405853-57451937 (+)
NZO/HlLtJ	ENSMUSG00225008271	protein coding gene	Chr1:61582443-61628309 (+)
PWK/PhJ	ENSLUMG00010024299	protein coding gene	Chr1:56865269-56914433 (+)
SPRET/EiJ	ENSMSPG00010022927	protein coding gene	Chr1:58780030-58835400 (+)
WSB/EiJ	ENSIUOG00005018480	protein coding gene	Chr1:57036396-57082424 (+)

Human Ortholog

CARF, calcium responsive transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARF, calcium responsive transcription factor
Synonyms

ALS2CR8, NYD-SP24
Links

HGNC:14435

NCBI Gene ID: 79800

UniProt: Q8N187
Chr Location

2q33.2; chr2:202912214-202988263 (+) GRCh38

MGI Vertebrate Homology

Carf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARF
Gene Tree

Carf

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

4
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Carf
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have aberrant learning and memory.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

654
Tissues

35
cDNA Data

7
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CARF

Xenbase carf

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All Sequences

102
RefSeq

44
UniProt

8
CCDS

CCDS14989.1, CCDS78592.1

Ensembl

ENSMUSG00000026017 (Evidence)
NCBI Gene

241066

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026017	Ensembl Gene Model \| MGI Sequence Detail	55707	C57BL/6J	± kb
transcript	ENSMUST00000187978	Ensembl \| MGI Sequence Detail	5463	Not Applicable
polypeptide	ENSMUSP00000141169	Ensembl \| MGI Sequence Detail	689	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000003977 calcium-responsive transcription factor

(term hierarchy)
InterPro Domains

IPR029309 Calcium-responsive transcription factor

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All nucleic 11

Genomic 2

cDNA 8

Primer pair 1

Antibodies 1

Microarray probesets 2

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Carf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6917	Chr1:60137413-60137449 (+)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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