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Lgi3 Gene Detail
Summary
  • Symbol
    Lgi3
  • Name
    leucine-rich repeat LGI family, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182619
    NCBI Gene: 213469
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70768125-70775764 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182619
 protein coding gene Chr14:70765982-70775764 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021541
 protein coding gene Chr14:65184496-65194066 (+)
A/J MGP_AJ_G0021500
 protein coding gene Chr14:63800143-63808218 (+)
AKR/J MGP_AKRJ_G0021476
 protein coding gene Chr14:65712082-65719471 (+)
BALB/cJ MGP_BALBcJ_G0021506
 protein coding gene Chr14:63563108-63570612 (+)
C3H/HeJ MGP_C3HHeJ_G0021283
 protein coding gene Chr14:65426753-65435510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021945
 protein coding gene Chr14:68097928-68105430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019485
 protein coding gene Chr14:61637575-61644936 (+)
CAST/EiJ MGP_CASTEiJ_G0020800
 protein coding gene Chr14:62021146-62030061 (+)
CBA/J MGP_CBAJ_G0021250
 protein coding gene Chr14:70237753-70245474 (+)
DBA/2J MGP_DBA2J_G0021373
 protein coding gene Chr14:63183909-63191493 (+)
FVB/NJ MGP_FVBNJ_G0021352
 protein coding gene Chr14:62613960-62621840 (+)
LP/J MGP_LPJ_G0021444
 protein coding gene Chr14:66428426-66435957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021381
 protein coding gene Chr14:69125934-69133609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021969
 protein coding gene Chr14:64975009-64982511 (+)
PWK/PhJ MGP_PWKPhJ_G0020544
 protein coding gene Chr14:59951312-59959042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020377
 protein coding gene Chr14:60902479-60909956 (+)
WSB/EiJ MGP_WSBEiJ_G0020853
 protein coding gene Chr14:65287130-65296174 (+)



Homology
more
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
  • Synonyms
    IDDMDS, LGIL4
  • Links
    NCBI Gene ID: 203190
    neXtProt AC: NX_Q8N145
    UniProt: Q8N145

  • Chr Location
    8p21.3; chr8:22146830-22157084 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have reduced and mis-localized Kv1 channel complexes in myelinated peripheral axons. A null IMPC allele shows enlarged kidney and spleen and thick skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    75
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033595 Ensembl Gene Model | MGI Sequence Detail 7640 C57BL/6J ±  kb
transcript ENSMUST00000047331 Ensembl | MGI Sequence Detail 3174 Not Applicable  
polypeptide ENSMUSP00000046705 Ensembl | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031155 leucine-rich repeat LGI family member 3
    (term hierarchy)
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR009039 EAR
    IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
    IPR051295 Leucine-rich glioma-inactivated/LGI-related
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
    IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
  • GlyGen
    Q8K406 3 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 1
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145695, MGI:2145791
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:77120 Gu W, et al., The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett. 2002 May 22;519(1-3):71-6
  • Latest
    J:345940 Miyazaki Y, et al., Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Rep. 2024 Jan 23;43(1):113634
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory