About   Help   FAQ
Spata20 Gene Detail
Summary
  • Symbol
    Spata20
  • Name
    spermatogenesis associated 20
  • Synonyms
    Tisp78
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183449
    NCBI Gene: 217116
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94369730-94376136 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183449
 protein coding gene Chr11:94369730-94377005 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018957
 protein coding gene Chr11:96574615-96581874 (-)
A/J MGP_AJ_G0018925
 protein coding gene Chr11:92711659-92718921 (-)
AKR/J MGP_AKRJ_G0018895
 protein coding gene Chr11:95596586-95603848 (-)
BALB/cJ MGP_BALBcJ_G0018898
 protein coding gene Chr11:93162088-93169352 (-)
C3H/HeJ MGP_C3HHeJ_G0018712
 protein coding gene Chr11:95679651-95686913 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019350
 protein coding gene Chr11:99581926-99589246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016981
 protein coding gene Chr11:90206322-90213570 (-)
CAST/EiJ MGP_CASTEiJ_G0018267
 protein coding gene Chr11:96396361-96403610 (-)
CBA/J MGP_CBAJ_G0018683
 protein coding gene Chr11:103720832-103728116 (-)
DBA/2J MGP_DBA2J_G0018791
 protein coding gene Chr11:92287415-92295196 (-)
FVB/NJ MGP_FVBNJ_G0018780
 protein coding gene Chr11:91708873-91716144 (-)
LP/J MGP_LPJ_G0018861
 protein coding gene Chr11:97119286-97126535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018807
 protein coding gene Chr11:103741781-103749036 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019390
 protein coding gene Chr11:95823910-95831190 (-)
PWK/PhJ MGP_PWKPhJ_G0018037
 protein coding gene Chr11:93220839-93228192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017827
 protein coding gene Chr11:95485413-95492711 (-)
WSB/EiJ MGP_WSBEiJ_G0018316
 protein coding gene Chr11:95704484-95711734 (-)



Homology
more
  • Human Ortholog
    SPATA20, spermatogenesis associated 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPATA20, spermatogenesis associated 20
  • Synonyms
    HEL-S-98, SSP411, Tisp78
  • Links
    NCBI Gene ID: 64847
    neXtProt AC: NX_Q8TB22
    UniProt: Q8TB22

  • Chr Location
    17q21.33; chr17:50543058-50555852 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Spata20 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, small testes, severe oligoasthenoteratozoospermia, and abnormal manchette morphology during spermiogenesis resulting in impaired sperm head formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217116 NCBI Gene Model | MGI Sequence Detail 6407 C57BL/6J ±  kb
    transcript NM_144827 RefSeq | MGI Sequence Detail 2606 Not Specified  
    polypeptide Q80YT5 UniProt | EBI | MGI Sequence Detail 790 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Diseases 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:262160 Liu M, et al., Disruption of Ssp411 causes impaired sperm head formation and male sterility in mice. Biochim Biophys Acta. 2018 Mar;1862(3):660-668
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory