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Cd276 Gene Detail
Summary
  • Symbol
    Cd276
  • Name
    CD276 antigen
  • Synonyms
    6030411F23Rik, B7-H3, B7h3, B7RP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183926
    NCBI Gene: 102657
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58431581-58462720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    916 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183926
 protein coding gene Chr9:58431581-58463437 (-)
129S1/SvImJ ENSMUSG00200035127
 protein coding gene Chr9:55558838-55590368 (-)
A/J ENSMUSG00195034972
 protein coding gene Chr9:55265948-55297481 (-)
AKR/J ENSMUSG00220030140
 protein coding gene Chr9:55400701-55431899 (-)
BALB/cJ ENSMUSG00180015767
 protein coding gene Chr9:55373327-55404471 (-)
C3H/HeJ ENSMUSG00175019377
 protein coding gene Chr9:55392659-55424194 (-)
C57BL/6NJ ENSMUSG00215014670
 protein coding gene Chr9:55366647-55397788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032295
 protein coding gene Chr9:55216293-55248841 (-)
CAST/EiJ ENSTCUG00005018731
 protein coding gene Chr9:55292187-55323341 (-)
CBA/J ENSMUSG00210039261
 protein coding gene Chr9:55501134-55532282 (-)
DBA/2J ENSMUSG00185037477
 protein coding gene Chr9:55517962-55549488 (-)
FVB/NJ ENSMUSG00205036938
 protein coding gene Chr9:55823957-55855152 (-)
JF1/MsJ ENSUMUG00000046343
 protein coding gene Chr9:55535475-55566896 (-)
LP/J ENSMUSG00230033137
 protein coding gene Chr9:55758524-55790045 (-)
NOD/ShiLtJ ENSMUSG00190036267
 protein coding gene Chr9:55585095-55616282 (-)
NZO/HlLtJ ENSMUSG00225026832
 protein coding gene Chr9:55803804-55834946 (-)
PWK/PhJ ENSLUMG00010032152
 protein coding gene Chr9:55495843-55527298 (-)
SPRET/EiJ ENSMSPG00010026247
 protein coding gene Chr9:56532282-56549299 (-)
WSB/EiJ ENSIUOG00005035204
 protein coding gene Chr9:54998780-55029960 (-)



Homology
more
  • Human Ortholog
    CD276, CD276 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD276, CD276 molecule
  • Synonyms
    4Ig-B7-H3, B7-H3, B7H3, B7RP-2
  • Links
    NCBI Gene ID: 80381
    UniProt: Q5ZPR3

  • Chr Location
    15q24.1; chr15:73683944-73714518 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 6 genetic backgrounds
    2 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in abnormal T helper 1 physiology. Mutant mice have an increased susceptibility to inflammation and autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    17
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035914 Ensembl Gene Model | MGI Sequence Detail 31140 C57BL/6J ±  kb
    transcript ENSMUST00000165365 Ensembl | MGI Sequence Detail 3603 Not Applicable  
    polypeptide ENSMUSP00000129418 Ensembl | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143194
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:371434 Liu Y, et al., Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development. Cell Metab. 2025 Aug 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory