Rassf9 MGI Mouse Gene Detail - MGI:2384307 - Ras association (RalGDS/AF-6) domain family (N-terminal) member 9

Symbol

Rassf9
Name

Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
Synonyms

MGC:41694, Pamci

Feature Type

protein coding gene
IDs

MGI:2384307
NCBI Gene: 237504
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:102348083-102385597 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 53.56 cM
Mapping Data

2 experiments

SNPs within 2kb

1208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384307	protein coding gene	Chr10:102348083-102385598 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017696	protein coding gene	Chr10:104495751-104532370 (+)
A/J	MGP_AJ_G0017675	protein coding gene	Chr10:100670489-100705694 (+)
AKR/J	MGP_AKRJ_G0017637	protein coding gene	Chr10:103622717-103660107 (+)
BALB/cJ	MGP_BALBcJ_G0017639	protein coding gene	Chr10:101004417-101039121 (+)
C3H/HeJ	MGP_C3HHeJ_G0017464	protein coding gene	Chr10:103641826-103679500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018096	protein coding gene	Chr10:108174503-108212104 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015775	protein coding gene	Chr10:95940202-95973693 (+)
CAST/EiJ	MGP_CASTEiJ_G0017025	protein coding gene	Chr10:103685836-103724897 (+)
CBA/J	MGP_CBAJ_G0017433	protein coding gene	Chr10:112259756-112298178 (+)
DBA/2J	MGP_DBA2J_G0017538	protein coding gene	Chr10:99769436-99807266 (+)
FVB/NJ	MGP_FVBNJ_G0017532	protein coding gene	Chr10:98853867-98891326 (+)
LP/J	MGP_LPJ_G0017612	protein coding gene	Chr10:105113949-105150958 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017562	protein coding gene	Chr10:113956851-113994421 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018134	protein coding gene	Chr10:103547631-103591836 (+)
PWK/PhJ	MGP_PWKPhJ_G0016807	protein coding gene	Chr10:99865804-99900638 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016597	protein coding gene	Chr10:102378878-102411540 (+)
WSB/EiJ	MGP_WSBEiJ_G0017085	protein coding gene	Chr10:103586684-103624739 (+)

Human Ortholog

RASSF9, Ras association domain family member 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASSF9, Ras association domain family member 9
Synonyms

PAMCI, P-CIP1, PCIP1
Links

HGNC:15739

NCBI Gene ID: 9182

neXtProt AC: NX_O75901

UniProt: O75901
Chr Location

12q21.31; chr12:85800703-85836409 (-) GRCh38

MGI Vertebrate Homology

Rassf9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASSF9
Gene Tree

Rassf9

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
6 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Rassf9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit premature lethality, alopecia, lung defects, and abnormal skin morphology and physiology.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

42
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS36048.1

Ensembl

ENSMUSG00000044921 (Evidence)
NCBI Gene

237504

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044921	Ensembl Gene Model \| MGI Sequence Detail	37515	C57BL/6J	± kb
transcript	ENSMUST00000219445	Ensembl \| MGI Sequence Detail	5294	Not Applicable
polypeptide	ENSMUSP00000151843	Ensembl \| MGI Sequence Detail	435	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013768 Ras association domain-containing protein 9

(term hierarchy)
InterPro Domains

IPR033593 N-terminal RASSF family

IPR000159 Ras-associating domain

IPR033633 Ras association domain-containing protein 9, RA domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 12

cDNA 12

Microarray probesets 2

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MGI:2143835

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 9
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Rassf9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95588	Chr10:102347634-102347639 (+)	-446 bp
Tssr95589	Chr10:102347893-102347924 (+)	-174 bp
Tssr95590	Chr10:102347944-102347966 (+)	-128 bp
Tssr95591	Chr10:102348077-102348153 (+)	32 bp
Tssr95592	Chr10:102348186-102348199 (+)	110 bp
Tssr95593	Chr10:102348255-102348270 (+)	180 bp
Tssr95594	Chr10:102348307-102348319 (+)	230 bp
Tssr95595	Chr10:102348344-102348382 (+)	280 bp
Tssr95596	Chr10:102355438-102355443 (+)	7,358 bp
Tssr95597	Chr10:102376122-102376142 (+)	28,049 bp
Tssr95598	Chr10:102382574-102382579 (+)	34,494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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