Rbm10 MGI Mouse Gene Detail - MGI:2384310 - RNA binding motif protein 10

Symbol

Rbm10
Name

RNA binding motif protein 10
Synonyms

E430039K10Rik, MGC:7826

Feature Type

protein coding gene
IDs

MGI:2384310
NCBI Gene: 236732
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:20483742-20517140 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.11 cM
Mapping Data

1 experiment

SNPs within 2kb

551 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384310	protein coding gene	ChrX:20483596-20517140 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035593	protein coding gene	ChrX:15502396-15537651 (+)
A/J	MGP_AJ_G0035570	protein coding gene	ChrX:15594887-15629186 (+)
AKR/J	MGP_AKRJ_G0035503	protein coding gene	ChrX:16126777-16167783 (+)
BALB/cJ	MGP_BALBcJ_G0035563	protein coding gene	ChrX:15341900-15375220 (+)
C3H/HeJ	MGP_C3HHeJ_G0035281	protein coding gene	ChrX:15721510-15758975 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036099	protein coding gene	ChrX:15908641-15950652 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032963	protein coding gene	ChrX:13849830-13880823 (+)
CAST/EiJ	MGP_CASTEiJ_G0034572	protein coding gene	ChrX:15016053-15050701 (+)
CBA/J	MGP_CBAJ_G0035250	protein coding gene	ChrX:16648493-16684728 (+)
DBA/2J	MGP_DBA2J_G0035402	protein coding gene	ChrX:15397732-15431596 (+)
FVB/NJ	MGP_FVBNJ_G0035348	protein coding gene	ChrX:15297755-15333302 (+)
LP/J	MGP_LPJ_G0035484	protein coding gene	ChrX:15752705-15787634 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035392	protein coding gene	ChrX:16903398-16939669 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036106	protein coding gene	ChrX:15413446-15451758 (+)
PWK/PhJ	MGP_PWKPhJ_G0034273	protein coding gene	ChrX:14585014-14618339 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034113	protein coding gene	ChrX:15395554-15434481 (+)
WSB/EiJ	MGP_WSBEiJ_G0034707	protein coding gene	ChrX:15284391-15320057 (+)

Human Ortholog

RBM10, RNA binding motif protein 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM10, RNA binding motif protein 10
Synonyms

DXS8237E, GPATC9, GPATCH9, MINAS-60, S1-1, TARPS, ZRANB5
Links

HGNC:9896

NCBI Gene ID: 8241

neXtProt AC: NX_P98175

UniProt: P0DW28, P98175
Chr Location

Xp11.3; chrX:47145221-47186813 (+) GRCh38

MGI Vertebrate Homology

Rbm10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM10
Gene Tree

Rbm10

Diseases

4 with human RBM10 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				TARP syndrome IDs TARP syndrome DOID:0111780 MESH:C536942 OMIM:311900 ORDO:2886 UMLS_CUI:C1839463

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
8 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

4
Gene trapped

14
Targeted

1
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele appear normal at E8.5.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

46
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

85
RefSeq

26
UniProt

4
CCDS

CCDS40885.1, CCDS53013.1, CCDS53014.1

Ensembl

ENSMUSG00000031060 (Evidence)
NCBI Gene

236732

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031060	Ensembl Gene Model \| MGI Sequence Detail	33399	C57BL/6J	± kb
transcript	ENSMUST00000115374	Ensembl \| MGI Sequence Detail	3564	Not Applicable
polypeptide	ENSMUSP00000111032	Ensembl \| MGI Sequence Detail	930	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013783 RNA-binding protein 10

(term hierarchy)
InterPro Domains

IPR000467 G-patch domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR041591 OCRE domain

IPR035618 RBM10, OCRE domain

IPR035979 RNA-binding domain superfamily

IPR034992 RNA-binding protein 10, RNA recognition motif 2

IPR000504 RNA recognition motif domain

IPR013087 Zinc finger C2H2-type

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily
GlyGen

Q99KG3 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 13

Primer pair 3

Microarray probesets 5

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MGI:2443912

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 17
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbm10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160650	ChrX:20483996-20484055 (+)	284 bp
Tssr160651	ChrX:20508121-20508158 (+)	24,398 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24