dblr Gene Detail

Summary

• Symbol
  dblr
• Name
  doubleridge

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:2384508
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr19:26305715-37234461 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, cytoband C
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  9 phenotype references
  

• All Mutations and Alleles
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygotes for a transgene-induced mutation exhibit an abnormally broad and flat apical ectodermal ridge leading to polydactyly and syndactyly of the forelimbs. Mutants often have kinked tails and microphthalmia or anophthalmia.

References

• Summaries
  All 10

  Phenotypes 9
• Earliest
  J:82633 Adamska M, et al., Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62
• Latest
  J:339662 Sung EA, et al., Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury. Am J Pathol. 2023 Sep;193(9):1130-1142