Cbr4 MGI Mouse Gene Detail - MGI:2384567

Symbol

Cbr4
Name

carbonyl reductase 4
Synonyms

A730083J17Rik, MGC:6971

Feature Type

protein coding gene
IDs

MGI:2384567
NCBI Gene: 234309
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:61940768-61956534 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 31.18 cM
Mapping Data

2 experiments

SNPs within 2kb

630 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384567	protein coding gene	Chr8:61940768-61959728 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033635	protein coding gene	Chr8:61408588-61428252 (+)
A/J	MGP_AJ_G0033617	protein coding gene	Chr8:58792734-58808441 (+)
AKR/J	MGP_AKRJ_G0033542	protein coding gene	Chr8:60483993-60499769 (+)
BALB/cJ	MGP_BALBcJ_G0033613	protein coding gene	Chr8:59043796-59059610 (+)
C3H/HeJ	MGP_C3HHeJ_G0033323	protein coding gene	Chr8:61151154-61167612 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034130	protein coding gene	Chr8:63744906-63761267 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031078	protein coding gene	Chr8:54037164-54053409 (+)
CAST/EiJ	MGP_CASTEiJ_G0032648	protein coding gene	Chr8:60568636-60584433 (+)
CBA/J	MGP_CBAJ_G0033301	protein coding gene	Chr8:66051437-66073946 (+)
DBA/2J	MGP_DBA2J_G0033455	protein coding gene	Chr8:58545963-58561776 (+)
FVB/NJ	MGP_FVBNJ_G0033396	protein coding gene	Chr8:57848413-57864133 (+)
LP/J	MGP_LPJ_G0033543	protein coding gene	Chr8:61379952-61399081 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033440	protein coding gene	Chr8:68158277-68175041 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034148	protein coding gene	Chr8:60739029-60756077 (+)
PWK/PhJ	MGP_PWKPhJ_G0032357	protein coding gene	Chr8:57851995-57868000 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032193	protein coding gene	Chr8:59705400-59721526 (+)
WSB/EiJ	MGP_WSBEiJ_G0032765	protein coding gene	Chr8:61067615-61083587 (+)

Human Ortholog

CBR4, carbonyl reductase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBR4, carbonyl reductase 4
Synonyms

SDR45C1
Links

HGNC:25891

NCBI Gene ID: 84869

neXtProt AC: NX_Q8N4T8

UniProt: Q8N4T8
Chr Location

4q32.3; chr4:168863770-169010275 (-) GRCh38

MGI Vertebrate Homology

Cbr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CBR4
Gene Tree

Cbr4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Cbr4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

32

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cbr4

ZFIN cbr4

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS40349.1

Ensembl

ENSMUSG00000031641 (Evidence)
NCBI Gene

234309

			Length	Strain/Species	Flank
genomic	234309	NCBI Gene Model \| MGI Sequence Detail	15767	C57BL/6J	± kb
transcript	NM_145595	RefSeq \| MGI Sequence Detail	1115	C57BL/6
polypeptide	Q91VT4	UniProt \| EBI \| MGI Sequence Detail	236	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005080 3-oxoacyl-[acyl-carrier-protein] reductase

(term hierarchy)
EC

1.1.1.100, 1.6.5.10
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q91VT4 1 site, 1 O-linked glycan (1 site)

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All nucleic 32

cDNA 32

Microarray probesets 3

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MGI:2443029

Summaries

All 36

Gene Ontology 6

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cbr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77489	Chr8:61940749-61940785 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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