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Rfwd3 Gene Detail
Summary
  • Symbol
    Rfwd3
  • Name
    ring finger and WD repeat domain 3
  • Synonyms
    MGC:27888
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384584
    NCBI Gene: 234736
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111997576-112026854 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    652 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384584
 protein coding gene Chr8:111997576-112026854 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0034117
 protein coding gene Chr8:109396403-109427348 (-)
AKR/J MGP_AKRJ_G0034044
 protein coding gene Chr8:112598913-112633615 (-)
BALB/cJ MGP_BALBcJ_G0034111
 protein coding gene Chr8:109577996-109607292 (-)
C3H/HeJ MGP_C3HHeJ_G0033822
 protein coding gene Chr8:113316285-113346698 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034631
 protein coding gene Chr8:118027136-118062213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031573
 protein coding gene Chr8:102367493-102397637 (-)
CAST/EiJ MGP_CASTEiJ_G0033149
 protein coding gene Chr8:112949239-112983591 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0033951
 protein coding gene Chr8:108682788-108714132 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0034041
 protein coding gene Chr8:114197173-114230969 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033941
 protein coding gene Chr8:124910785-124947927 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0032691
 protein coding gene Chr8:111232548-111263296 (-)
WSB/EiJ MGP_WSBEiJ_G0033265
 protein coding gene Chr8:113249500-113287101 (-)



Homology
more
  • Human Ortholog
    RFWD3, ring finger and WD repeat domain 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFWD3, ring finger and WD repeat domain 3
  • Synonyms
    FANCW, RNF201
  • Links
    NCBI Gene ID: 55159
    neXtProt AC: NX_Q6PCD5
    UniProt: Q6PCD5

  • Chr Location
    16q23.1; chr16:74621399-74666877 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RFWD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female and male fertility (possibly infertility), gonad atrophy, oligospermia, failure of follicular development, increased cellular sensitivity to MMC treatment, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    131
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234736 NCBI Gene Model | MGI Sequence Detail 29279 C57BL/6J ±  kb
    transcript NM_146218 RefSeq | MGI Sequence Detail 4443 C57BL/6  
    polypeptide Q8CIK8 UniProt | EBI | MGI Sequence Detail 774 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 131

      Microarray probesets 5
    References
    more
    • Summaries
      All 32
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:299518 Markiewicz-Potoczny M, et al., TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Nature. 2021 Jan;589(7840):110-115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory