Zfp553 MGI Mouse Gene Detail - MGI:2384725

Symbol

Zfp553
Name

zinc finger protein 553
Synonyms

2600009K23Rik, C330013F15Rik, ENSMUSG00000054461, MGC:31231

Feature Type

protein coding gene
IDs

MGI:2384725
NCBI Gene: 233887
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:126832233-126837351 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.40 cM
Mapping Data

3 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384725	protein coding gene	Chr7:126832233-126837369 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033027	protein coding gene	Chr7:131568585-131573703 (+)
A/J	MGP_AJ_G0033010	protein coding gene	Chr7:128064647-128069669 (+)
AKR/J	MGP_AKRJ_G0032942	protein coding gene	Chr7:131317867-131322986 (+)
BALB/cJ	MGP_BALBcJ_G0033015	protein coding gene	Chr7:127726446-127732502 (+)
C3H/HeJ	MGP_C3HHeJ_G0032725	protein coding gene	Chr7:131252452-131257570 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033521	protein coding gene	Chr7:136677704-136682822 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030493	protein coding gene	Chr7:129277466-129282443 (+)
CAST/EiJ	MGP_CASTEiJ_G0032054	protein coding gene	Chr7:123047096-123052208 (+)
CBA/J	MGP_CBAJ_G0032698	protein coding gene	Chr7:141279410-141284528 (+)
DBA/2J	MGP_DBA2J_G0032850	protein coding gene	Chr7:126036492-126042213 (+)
FVB/NJ	MGP_FVBNJ_G0032803	protein coding gene	Chr7:125889466-125894951 (+)
LP/J	MGP_LPJ_G0032944	protein coding gene	Chr7:133031675-133036793 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032835	protein coding gene	Chr7:142425337-142430455 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033540	protein coding gene	Chr7:130332951-130338069 (+)
PWK/PhJ	MGP_PWKPhJ_G0031761	protein coding gene	Chr7:119045648-119050852 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031607	protein coding gene	Chr7:117167818-117175523 (+)
WSB/EiJ	MGP_WSBEiJ_G0032166	protein coding gene	Chr7:131305809-131310799 (+)

Human Ortholog

ZNF48, zinc finger protein 48

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF48, zinc finger protein 48
Synonyms

ZNF553
Links

HGNC:13114

NCBI Gene ID: 197407

neXtProt AC: NX_Q96MX3

UniProt: Q96MX3
Chr Location

16p11.2

MGI Vertebrate Homology

Zfp553 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF48
Gene Tree

Zfp553

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Gene trapped

42
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a transgenic gene disruption exhibit complete embryonic lethality during organogenesis.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

925
Tissues

59
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS21860.1

Ensembl

ENSMUSG00000045598 (Evidence)
NCBI Gene

233887

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045598	Ensembl Gene Model \| MGI Sequence Detail	5119	C57BL/6J	± kb
transcript	ENSMUST00000106312	Ensembl \| MGI Sequence Detail	3342	Not Applicable
polypeptide	ENSMUSP00000101919	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017920 zinc finger protein 48

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 3

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MGI:1919370, MGI:2141958, MGI:2441902, MGI:3704301

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Zfp553:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69182	Chr7:126832056-126832076 (+)	-167 bp
Tssr69183	Chr7:126832216-126832245 (+)	-2 bp
Tssr69184	Chr7:126832399-126832489 (+)	211 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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