Phf21a MGI Mouse Gene Detail - MGI:2384756

Symbol

Phf21a
Name

PHD finger protein 21A
Synonyms

80kDa, Bhc80, Braf35/HDAC complex (Bhc), D030065N23Rik, MGC:29190, PFTF1

Feature Type

protein coding gene
IDs

MGI:2384756
NCBI Gene: 192285
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:92014451-92195011 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.80 cM
Mapping Data

3 experiments

SNPs within 2kb

2973 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384756	protein coding gene	Chr2:92014096-92195011 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026163	protein coding gene	Chr2:93599359-93795330 (+)
A/J	MGP_AJ_G0026124	protein coding gene	Chr2:89818526-89998296 (+)
AKR/J	MGP_AKRJ_G0026105	protein coding gene	Chr2:92296038-92485807 (+)
BALB/cJ	MGP_BALBcJ_G0026133	protein coding gene	Chr2:90001456-90182668 (+)
C3H/HeJ	MGP_C3HHeJ_G0025884	protein coding gene	Chr2:92608107-92793143 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026584	protein coding gene	Chr2:96814009-97010228 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023975	protein coding gene	Chr2:86310911-86489839 (+)
CAST/EiJ	MGP_CASTEiJ_G0025349	protein coding gene	Chr2:93044480-93339664 (+)
CBA/J	MGP_CBAJ_G0025862	protein coding gene	Chr2:100197953-100396595 (+)
DBA/2J	MGP_DBA2J_G0025998	protein coding gene	Chr2:89410153-89591358 (+)
FVB/NJ	MGP_FVBNJ_G0025961	protein coding gene	Chr2:88518895-88701620 (+)
LP/J	MGP_LPJ_G0026102	protein coding gene	Chr2:93795059-93991395 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025987	protein coding gene	Chr2:103159488-103355051 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026638	protein coding gene	Chr2:92382720-92571136 (+)
PWK/PhJ	MGP_PWKPhJ_G0025084	protein coding gene	Chr2:89057525-89336900 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024885	protein coding gene	Chr2:91956651-92140591 (+)
WSB/EiJ	MGP_WSBEiJ_G0025416	protein coding gene	Chr2:92900248-93189177 (+)

Human Ortholog

PHF21A, PHD finger protein 21A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHF21A, PHD finger protein 21A
Synonyms

BHC80, BM-006, IDDBCS, NEDMS
Links

HGNC:24156

NCBI Gene ID: 51317

neXtProt AC: NX_Q96BD5

UniProt: Q96BD5
Chr Location

11p11.2; chr11:45929319-46121454 (-) GRCh38

MGI Vertebrate Homology

Phf21a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PHF21A
Gene Tree

Phf21a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

143
Chemically induced (other)

1
Gene trapped

138
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Phf21a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

183 strains or lines available

Mice homozygous for a knock-out allele exhibit neonatal lethality and insufficient milk-sucking behavior.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

79
cDNA Data

80
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phf21a

ZFIN phf21aa, phf21ab

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All Sequences

190
RefSeq

104
UniProt

16
CCDS

CCDS16442.1, CCDS50644.1, CCDS50645.1, CCDS84556.1

Ensembl

ENSMUSG00000058318 (Evidence)
NCBI Gene

192285

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058318	Ensembl Gene Model \| MGI Sequence Detail	180561	C57BL/6J	± kb
transcript	ENSMUST00000111293	Ensembl \| MGI Sequence Detail	3900	Not Applicable
polypeptide	ENSMUSP00000106924	Ensembl \| MGI Sequence Detail	688	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000012648 PHD finger protein 21A

(term hierarchy)
InterPro Domains

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

Q6ZPK0 8 sites, 1 O-linked glycan (8 sites)

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All nucleic 87

Genomic 1

cDNA 81

Primer pair 5

Microarray probesets 5

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MGI:3026971

Summaries

All 54

Developmental Gene Expression 11

Gene Ontology 7

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:291493 Najas S, et al., A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Development. 2020 Jul 13;147(13):dev187005

TSS for Phf21a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18933	Chr2:92014120-92014212 (+)	-285 bp
Tssr18934	Chr2:92014523-92014563 (+)	92 bp
Tssr18935	Chr2:92014613-92014655 (+)	183 bp
Tssr18936	Chr2:92014656-92014670 (+)	212 bp
Tssr18937	Chr2:92015752-92015781 (+)	1,316 bp
Tssr18938	Chr2:92015783-92015808 (+)	1,345 bp
Tssr18939	Chr2:92015812-92015839 (+)	1,375 bp
Tssr18940	Chr2:92020119-92020162 (+)	5,690 bp
Tssr18941	Chr2:92076552-92076571 (+)	62,111 bp
Tssr18942	Chr2:92174928-92174940 (+)	160,483 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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