Creb3l3 MGI Mouse Gene Detail - MGI:2384786 - cAMP responsive element binding protein 3-like 3

Symbol

Creb3l3
Name

cAMP responsive element binding protein 3-like 3
Synonyms

CREB-H, D10Bur1e

Feature Type

protein coding gene
IDs

MGI:2384786
NCBI Gene: 208677
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:80920163-80934706 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

425 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384786	protein coding gene	Chr10:80920158-80934708 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017535	protein coding gene	Chr10:81761953-81778219 (-)
A/J	MGP_AJ_G0017513	protein coding gene	Chr10:78880146-78894561 (-)
AKR/J	MGP_AKRJ_G0017474	protein coding gene	Chr10:81044010-81061374 (-)
BALB/cJ	MGP_BALBcJ_G0017475	protein coding gene	Chr10:79094049-79109180 (-)
C3H/HeJ	MGP_C3HHeJ_G0017298	protein coding gene	Chr10:81126276-81146691 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017929	protein coding gene	Chr10:84575888-84591131 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015618	protein coding gene	Chr10:75084528-75093404 (-)
CAST/EiJ	MGP_CASTEiJ_G0016865	protein coding gene	Chr10:81366829-81384163 (-)
CBA/J	MGP_CBAJ_G0017270	protein coding gene	Chr10:87864745-87881909 (-)
DBA/2J	MGP_DBA2J_G0017376	protein coding gene	Chr10:78074342-78089042 (-)
FVB/NJ	MGP_FVBNJ_G0017370	protein coding gene	Chr10:77316731-77331306 (-)
LP/J	MGP_LPJ_G0017447	protein coding gene	Chr10:82213353-82230009 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017396	protein coding gene	Chr10:89736978-89752757 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017970	protein coding gene	Chr10:81036100-81051705 (-)
PWK/PhJ	MGP_PWKPhJ_G0016646	protein coding gene	Chr10:77974992-77991875 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016436	protein coding gene	Chr10:79985685-80010006 (-)
WSB/EiJ	MGP_WSBEiJ_G0016925	protein coding gene	Chr10:81073094-81089216 (-)

Human Ortholog

CREB3L3, cAMP responsive element binding protein 3 like 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CREB3L3, cAMP responsive element binding protein 3 like 3
Synonyms

CREB-H, CREBH, HYST1481, HYTG2
Links

HGNC:18855

NCBI Gene ID: 84699

UniProt: Q68CJ9
Chr Location

19p13.3; chr19:4153631-4173054 (+) GRCh38

MGI Vertebrate Homology

Creb3l3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CREB3L3
Gene Tree

Creb3l3

less

Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Creb3l3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a knock-out allele are viable and healthy but exhibit reduced expression of acute phase response proteins following treatment with tunicamycin that induces ER stress. Mice homozygous for a different knock-out allele exhibit resistanceto sulpyrine-induced shock.

less

All GO Annotations

37
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

72
cDNA Data

60
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CREB3L3

Xenbase creb3l3

ZFIN creb3l3a, creb3l3b

less

All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS24043.1

Ensembl

ENSMUSG00000035041 (Evidence)
NCBI Gene

208677

			Length	Strain/Species	Flank
genomic	208677	NCBI Gene Model \| MGI Sequence Detail	14544	C57BL/6J	± kb
transcript	NM_145365	RefSeq \| MGI Sequence Detail	2283	ZRU/MplStud
polypeptide	Q91XE9	UniProt \| EBI \| MGI Sequence Detail	479	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000005858 cyclic AMP-responsive element-binding protein 3-like protein 3

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR051381 cAMP-responsive element-binding ATF subfamily
GlyGen

Q91XE9 4 sites

less

All nucleic 64

cDNA 60

Primer pair 4

Microarray probesets 3

less

MGI:1346038

Summaries

All 77

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 35
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:367634 Chan P, et al., Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic de novo lipogenesis by mediating epididymal fat insulin resistance. Int J Biol Sci. 2025;21(6):2568-2588

TSS for Creb3l3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98558	Chr10:80928487-80928498 (-)	6,213 bp
Tssr98557	Chr10:80928409-80928467 (-)	6,268 bp
Tssr98556	Chr10:80928388-80928395 (-)	6,314 bp
Tssr98555	Chr10:80928374-80928380 (-)	6,329 bp
Tssr98554	Chr10:80925167-80925176 (-)	9,534 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/09/2025 MGI 6.24