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Eif2b1 Gene Detail
Summary
  • Symbol
    Eif2b1
  • Name
    eukaryotic translation initiation factor 2B, subunit alpha
  • Synonyms
    26kDa, D5Ertd406e, EIF2B, EIF2BA, MGC:6458
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384802
    NCBI Gene: 209354
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124708277-124717194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384802
 protein coding gene Chr5:124708276-124717194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030101
 protein coding gene Chr5:128402441-128411383 (-)
A/J MGP_AJ_G0030066
 protein coding gene Chr5:123043551-123052543 (-)
AKR/J MGP_AKRJ_G0030002
 protein coding gene Chr5:127016186-127025094 (-)
BALB/cJ MGP_BALBcJ_G0030077
 protein coding gene Chr5:124382710-124391935 (-)
C3H/HeJ MGP_C3HHeJ_G0029794
 protein coding gene Chr5:127627312-127636164 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030530
 protein coding gene Chr5:133386862-133395716 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027756
 protein coding gene Chr5:117582737-117592268 (-)
CAST/EiJ MGP_CASTEiJ_G0029203
 protein coding gene Chr5:126743205-126752128 (-)
CBA/J MGP_CBAJ_G0029764
 protein coding gene Chr5:138605140-138614015 (-)
DBA/2J MGP_DBA2J_G0029914
 protein coding gene Chr5:123064541-123074792 (-)
FVB/NJ MGP_FVBNJ_G0029870
 protein coding gene Chr5:122112345-122121214 (-)
LP/J MGP_LPJ_G0030003
 protein coding gene Chr5:128934089-128945894 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029901
 protein coding gene Chr5:142173166-142182031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030571
 protein coding gene Chr5:126636752-126645617 (-)
PWK/PhJ MGP_PWKPhJ_G0028917
 protein coding gene Chr5:121889644-121898731 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028754
 protein coding gene Chr5:124264501-124273016 (-)
WSB/EiJ MGP_WSBEiJ_G0029277
 protein coding gene Chr5:127320486-127330033 (-)



Homology
more
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2B1, eukaryotic translation initiation factor 2B subunit alpha
  • Synonyms
    EIF2B, EIF2BA, EIF2Balpha, VWM1
  • Links
    NCBI Gene ID: 1967
    neXtProt AC: NX_Q14232
    UniProt: Q14232

  • Chr Location
    12q24.31; chr12:123620406-123633766 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF2B1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    86
  • cDNA Data
    160
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209354 NCBI Gene Model | MGI Sequence Detail 8918 C57BL/6J ±  kb
transcript NM_145371 RefSeq | MGI Sequence Detail 2012 C57BL/6  
polypeptide Q99LC8 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006962 translation initiation factor eIF2B subunit alpha
    (term hierarchy)
  • InterPro Domains
    IPR051501 Eukaryotic initiation factor 2B subunits alpha/beta/delta
    IPR042529 Initiation factor 2B-like, C-terminal
    IPR000649 Initiation factor 2B-related
    IPR037171 NagB/RpiA transferase-like
    IPR042528 Translation initiation factor eIF-2B subunit alpha, N-terminal
  • GlyGen
    Q99LC8 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 163
    cDNA 160
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196215
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:343394 Kashiwagi K, et al., Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. J Struct Funct Genomics. 2016 Mar;17(1):33-8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory