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Tbc1d12 Gene Detail
Summary
  • Symbol
    Tbc1d12
  • Name
    TBC1D12: TBC1 domain family, member 12
  • Synonyms
    MGC:38216
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384803
    NCBI Gene: 209478
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38825035-38908103 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 33.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1849 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384803
protein coding gene Chr19:38825023-38908367 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025095
protein coding gene Chr19:37925211-38017440 (+)
A/J MGP_AJ_G0025071
protein coding gene Chr19:36087755-36171477 (+)
AKR/J MGP_AKRJ_G0025039
protein coding gene Chr19:37276156-37372097 (+)
BALB/cJ MGP_BALBcJ_G0025069
protein coding gene Chr19:36185632-36269348 (+)
C3H/HeJ MGP_C3HHeJ_G0024828
protein coding gene Chr19:37396701-37484374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025510
protein coding gene Chr19:38999731-39087841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022929
protein coding gene Chr19:35406038-35481680 (+)
CAST/EiJ MGP_CASTEiJ_G0024295
protein coding gene Chr19:37253193-37349822 (+)
CBA/J MGP_CBAJ_G0024805
protein coding gene Chr19:40837258-40956702 (+)
DBA/2J MGP_DBA2J_G0024937
protein coding gene Chr19:35920951-36006408 (+)
FVB/NJ MGP_FVBNJ_G0024898
protein coding gene Chr19:35752364-35834905 (+)
LP/J MGP_LPJ_G0025023
protein coding gene Chr19:38007778-38096189 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024929
protein coding gene Chr19:40566569-40663543 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025568
protein coding gene Chr19:37408908-37500299 (+)
PWK/PhJ MGP_PWKPhJ_G0024047
protein coding gene Chr19:35797541-35883434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023847
protein coding gene Chr19:36242768-36328136 (+)
WSB/EiJ MGP_WSBEiJ_G0024362
protein coding gene Chr19:37497561-37583621 (+)



Homology
more
  • Human Ortholog
    TBC1D12, TBC1 domain family member 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D12, TBC1 domain family member 12
  • Links
    NCBI Gene ID: 23232
    neXtProt AC: NX_O60347
    UniProt: O60347

  • Chr Location
    10q23.33; chr10:94402541-94536332 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209478 NCBI Gene Model | MGI Sequence Detail 83069 C57BL/6J ±  kb
    transcript NR_175806 RefSeq | MGI Sequence Detail 4052 C57BL/6  
    polypeptide Q6A039 UniProt | EBI | MGI Sequence Detail 696 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory