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Mtss1 Gene Detail
Summary
  • Symbol
    Mtss1
  • Name
    MTSS I-BAR domain containing 1
  • Synonyms
    2310003N14Rik, D130001D01Rik, MGC:37896, MIM, mKIAA0429
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384818
    NCBI Gene: 211401
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:58813083-58953854 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4573 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384818
 protein coding gene Chr15:58813083-58955805 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021881
 protein coding gene Chr15:58144729-58286449 (-)
A/J MGP_AJ_G0021841
 protein coding gene Chr15:55873640-56015890 (-)
AKR/J MGP_AKRJ_G0021822
 protein coding gene Chr15:57413466-57556810 (-)
BALB/cJ MGP_BALBcJ_G0021848
 protein coding gene Chr15:56093886-56235461 (-)
C3H/HeJ MGP_C3HHeJ_G0021622
 protein coding gene Chr15:57547764-57693856 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022287
 protein coding gene Chr15:60394107-60541280 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019824
 protein coding gene Chr15:52966990-53105192 (-)
CAST/EiJ MGP_CASTEiJ_G0021139
 protein coding gene Chr15:58202459-58360264 (-)
CBA/J MGP_CBAJ_G0021591
 protein coding gene Chr15:62496529-62651283 (-)
DBA/2J MGP_DBA2J_G0021715
 protein coding gene Chr15:55788686-55929958 (-)
FVB/NJ MGP_FVBNJ_G0021693
 protein coding gene Chr15:54831307-54974794 (-)
LP/J MGP_LPJ_G0021785
 protein coding gene Chr15:58004337-58154659 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021717
 protein coding gene Chr15:67550057-67695505 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022310
 protein coding gene Chr15:57819595-57965790 (-)
PWK/PhJ MGP_PWKPhJ_G0020884
 protein coding gene Chr15:55793130-55942376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020721
 protein coding gene Chr15:57620097-57772633 (-)
WSB/EiJ MGP_WSBEiJ_G0021194
 protein coding gene Chr15:57822323-57975181 (-)



Homology
more
  • Human Ortholog
    MTSS1, MTSS I-BAR domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTSS1, MTSS I-BAR domain containing 1
  • Synonyms
    MIM, MIMA, MIMB
  • Links
    NCBI Gene ID: 9788
    neXtProt AC: NX_O43312
    UniProt: O43312

  • Chr Location
    8q24.13; chr8:124550784-124728473 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mtss1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    52
  • cDNA Data
    15
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022353 Ensembl Gene Model | MGI Sequence Detail 140772 C57BL/6J ±  kb
    transcript ENSMUST00000080371 Ensembl | MGI Sequence Detail 4938 Not Applicable  
    polypeptide ENSMUSP00000079239 Ensembl | MGI Sequence Detail 759 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 15
      Primer pair 4
      Other 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917337, MGI:2442868
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 9
      Phenotypes 50
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:349009 Kim N, et al., Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1. Elife. 2024 Mar 25;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory