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Nepro Gene Detail
Summary
  • Symbol
    Nepro
  • Name
    nucleolus and neural progenitor protein
  • Synonyms
    BC027231, MGC:27931
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384836
    NCBI Gene: 212547
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:44544664-44557647 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 29.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384836
 protein coding gene Chr16:44544645-44559994 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022841
 protein coding gene Chr16:43490697-43503678 (+)
A/J MGP_AJ_G0022806
 protein coding gene Chr16:41542436-41555446 (+)
AKR/J MGP_AKRJ_G0022778
 protein coding gene Chr16:42867222-42881579 (+)
BALB/cJ MGP_BALBcJ_G0022807
 protein coding gene Chr16:41533323-41546303 (+)
C3H/HeJ MGP_C3HHeJ_G0022571
 protein coding gene Chr16:43071239-43084221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023254
 protein coding gene Chr16:44479225-44492208 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020769
 protein coding gene Chr16:41579419-41593113 (+)
CAST/EiJ MGP_CASTEiJ_G0022097
 protein coding gene Chr16:43265541-43278850 (+)
CBA/J MGP_CBAJ_G0022542
 protein coding gene Chr16:46368150-46381131 (+)
DBA/2J MGP_DBA2J_G0022674
 protein coding gene Chr16:41274897-41287879 (+)
FVB/NJ MGP_FVBNJ_G0022649
 protein coding gene Chr16:41232675-41245656 (+)
LP/J MGP_LPJ_G0022742
 protein coding gene Chr16:43218237-43231974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022668
 protein coding gene Chr16:45746567-45759548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023269
 protein coding gene Chr16:42899874-42912856 (+)
PWK/PhJ MGP_PWKPhJ_G0021837
 protein coding gene Chr16:41653490-41666822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021668
 protein coding gene Chr16:42806636-42821598 (+)
WSB/EiJ MGP_WSBEiJ_G0022141
 protein coding gene Chr16:42994998-43007979 (+)



Homology
more
  • Human Ortholog
    NEPRO, nucleolus and neural progenitor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEPRO, nucleolus and neural progenitor protein
  • Synonyms
    ANXD3, C3orf17, NET17
  • Links
    NCBI Gene ID: 25871
    neXtProt AC: NX_Q6NW34
    UniProt: Q6NW34

  • Chr Location
    3q13.2; chr3:113002444-113019861 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEPRO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to implantation with a failure to form a blastocyst.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    74
  • cDNA Data
    49
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036208 Ensembl Gene Model | MGI Sequence Detail 12984 C57BL/6J ±  kb
transcript ENSMUST00000048788 Ensembl | MGI Sequence Detail 2866 Not Applicable  
polypeptide ENSMUSP00000038779 Ensembl | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000059857 nucleolus and neural progenitor protein
    (term hierarchy)
  • InterPro Domains
    IPR052835 Nucleolus and neural progenitor-associated protein
    IPR027951 Nucleolus and neural progenitor protein-like, N-terminal domain
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory