Pdlim2 MGI Mouse Gene Detail - MGI:2384850

Symbol

Pdlim2
Name

PDZ and LIM domain 2
Synonyms

4732462F18Rik, MGC:37634, mystique, SLIM

Feature Type

protein coding gene
IDs

MGI:2384850
NCBI Gene: 213019
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:70401667-70415130 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.26 cM
Mapping Data

2 experiments

SNPs within 2kb

344 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384850	protein coding gene	Chr14:70401667-70415140 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021532	protein coding gene	Chr14:64787156-64802796 (-)
A/J	MGP_AJ_G0021491	protein coding gene	Chr14:63428407-63440736 (-)
AKR/J	MGP_AKRJ_G0021467	protein coding gene	Chr14:65329289-65343476 (-)
BALB/cJ	MGP_BALBcJ_G0021497	protein coding gene	Chr14:63188741-63201199 (-)
C3H/HeJ	MGP_C3HHeJ_G0021274	protein coding gene	Chr14:65041315-65054618 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021936	protein coding gene	Chr14:67704893-67719262 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019476	protein coding gene	Chr14:61264856-61277820 (-)
CAST/EiJ	MGP_CASTEiJ_G0020791	protein coding gene	Chr14:61624095-61637795 (-)
CBA/J	MGP_CBAJ_G0021241	protein coding gene	Chr14:69819852-69835954 (-)
DBA/2J	MGP_DBA2J_G0021364	protein coding gene	Chr14:62809873-62822627 (-)
FVB/NJ	MGP_FVBNJ_G0021343	protein coding gene	Chr14:62237292-62250407 (-)
LP/J	MGP_LPJ_G0021435	protein coding gene	Chr14:66038391-66055897 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021372	protein coding gene	Chr14:68734796-68748631 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021960	protein coding gene	Chr14:64592740-64606054 (-)
PWK/PhJ	MGP_PWKPhJ_G0020535	protein coding gene	Chr14:59571640-59584560 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020368	protein coding gene	Chr14:60517085-60532643 (-)
WSB/EiJ	MGP_WSBEiJ_G0020844	protein coding gene	Chr14:64895705-64909662 (-)

Human Ortholog

PDLIM2, PDZ and LIM domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDLIM2, PDZ and LIM domain 2
Synonyms

MYSTIQUE, SLIM
Links

HGNC:13992

NCBI Gene ID: 64236

neXtProt AC: NX_Q96JY6

UniProt: Q96JY6
Chr Location

8p21.3; chr8:22578279-22598026 (+) GRCh38

MGI Vertebrate Homology

Pdlim2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDLIM2
Gene Tree

Pdlim2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Pdlim2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.

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All GO Annotations

24
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

68
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdlim2

ZFIN pdlim2

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All Sequences

60
RefSeq

12
UniProt

5
CCDS

CCDS27248.1

Ensembl

ENSMUSG00000022090 (Evidence)
NCBI Gene

213019

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022090	Ensembl Gene Model \| MGI Sequence Detail	13464	C57BL/6J	± kb
transcript	ENSMUST00000022681	Ensembl \| MGI Sequence Detail	1523	Not Applicable
polypeptide	ENSMUSP00000022681	Ensembl \| MGI Sequence Detail	349	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012509 PDZ and LIM domain protein 2

(term hierarchy)
PDB

1VB7
InterPro Domains

IPR050604 PDZ and LIM domain-containing

IPR031847 PDZ and LIM domain protein 1-4/Zasp-like, middle domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001781 Zinc finger, LIM-type
GlyGen

Q8R1G6 1 site, 1 O-linked glycan (1 site)

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All nucleic 68

cDNA 68

Microarray probesets 2

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MGI:1915048

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305911 Li L, et al., PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 Mar 8;6(5)

TSS for Pdlim2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129531	Chr14:70415178-70415196 (-)	-57 bp
Tssr129530	Chr14:70415117-70415145 (-)	-1 bp
Tssr129529	Chr14:70414236-70414273 (-)	875 bp
Tssr129528	Chr14:70412846-70412892 (-)	2,261 bp
Tssr129527	Chr14:70412805-70412844 (-)	2,305 bp
Tssr129526	Chr14:70412755-70412778 (-)	2,363 bp
Tssr129525	Chr14:70411356-70411359 (-)	3,772 bp
Tssr129524	Chr14:70405470-70405510 (-)	9,640 bp
Tssr129523	Chr14:70405460-70405469 (-)	9,665 bp
Tssr129522	Chr14:70405441-70405453 (-)	9,683 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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