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Duoxa1 Gene Detail
Summary
  • Symbol
    Duoxa1
  • Name
    dual oxidase maturation factor 1
  • Synonyms
    MGC:25550, Nip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384861
    NCBI Gene: 213696
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122134012-122144255 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384861
 protein coding gene Chr2:122132672-122144255 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026412
 protein coding gene Chr2:125303883-125315315 (-)
A/J MGP_AJ_G0026374
 protein coding gene Chr2:120178319-120189726 (-)
AKR/J MGP_AKRJ_G0026351
 protein coding gene Chr2:123544826-123556270 (-)
BALB/cJ MGP_BALBcJ_G0026386
 protein coding gene Chr2:120408001-120419442 (-)
C3H/HeJ MGP_C3HHeJ_G0026131
 protein coding gene Chr2:124027162-124038655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026833
 protein coding gene Chr2:129370169-129381722 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024212
 protein coding gene Chr2:115148219-115159703 (-)
CAST/EiJ MGP_CASTEiJ_G0025593
 protein coding gene Chr2:124368351-124379921 (-)
CBA/J MGP_CBAJ_G0026110
 protein coding gene Chr2:133920534-133931966 (-)
DBA/2J MGP_DBA2J_G0026247
 protein coding gene Chr2:119574658-119586100 (-)
FVB/NJ MGP_FVBNJ_G0026209
 protein coding gene Chr2:118367569-118379002 (-)
LP/J MGP_LPJ_G0026349
 protein coding gene Chr2:125549161-125560593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026229
 protein coding gene Chr2:138131071-138142504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026888
 protein coding gene Chr2:123662061-123673499 (-)
PWK/PhJ MGP_PWKPhJ_G0025329
 protein coding gene Chr2:119188361-119200108 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025129
 protein coding gene Chr2:122805212-122816758 (-)
WSB/EiJ MGP_WSBEiJ_G0025665
 protein coding gene Chr2:124522973-124534406 (-)



Homology
more
  • Human Ortholog
    DUOXA1, dual oxidase maturation factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUOXA1, dual oxidase maturation factor 1
  • Synonyms
    mol, NIP, NUMBIP
  • Links
    NCBI Gene ID: 90527
    neXtProt AC: NX_Q1HG43
    UniProt: Q1HG43

  • Chr Location
    15q21.1; chr15:45117366-45129938 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    18
  • cDNA Data
    31
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 213696 NCBI Gene Model | MGI Sequence Detail 10244 C57BL/6J ±  kb
transcript NM_001305262 RefSeq | MGI Sequence Detail 1559 C57BL/6  
polypeptide Q8VE49 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:334724 Duan J, et al., Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut. Immunity. 2023 Mar 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory