Tspan8 MGI Mouse Gene Detail - MGI:2384918

Symbol

Tspan8
Name

tetraspanin 8
Synonyms

E330007O21Rik, Tm4sf3

Feature Type

protein coding gene
IDs

MGI:2384918
NCBI Gene: 216350
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:115652737-115685798 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 63.51 cM
Mapping Data

3 experiments

SNPs within 2kb

1078 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384918	protein coding gene	Chr10:115652722-115685798 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017741	protein coding gene	Chr10:118552611-118587464 (+)
A/J	MGP_AJ_G0017717	protein coding gene	Chr10:114001936-114035729 (+)
AKR/J	MGP_AKRJ_G0017679	protein coding gene	Chr10:117289815-117322309 (+)
BALB/cJ	MGP_BALBcJ_G0017680	protein coding gene	Chr10:114397070-114433411 (+)
C3H/HeJ	MGP_C3HHeJ_G0017505	protein coding gene	Chr10:117525419-117562468 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018137	protein coding gene	Chr10:122676084-122713177 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015817	protein coding gene	Chr10:108617984-108649969 (+)
CAST/EiJ	MGP_CASTEiJ_G0017067	protein coding gene	Chr10:117780330-117816061 (+)
CBA/J	MGP_CBAJ_G0017474	protein coding gene	Chr10:127463282-127503876 (+)
DBA/2J	MGP_DBA2J_G0017579	protein coding gene	Chr10:113144097-113179959 (+)
FVB/NJ	MGP_FVBNJ_G0017574	protein coding gene	Chr10:112091388-112125935 (+)
LP/J	MGP_LPJ_G0017654	protein coding gene	Chr10:119128274-119163418 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017603	protein coding gene	Chr10:130399172-130433905 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018175	protein coding gene	Chr10:117352365-117388633 (+)
PWK/PhJ	MGP_PWKPhJ_G0016849	protein coding gene	Chr10:113224060-113262726 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016639	protein coding gene	Chr10:116142417-116176731 (+)
WSB/EiJ	MGP_WSBEiJ_G0017127	protein coding gene	Chr10:117529749-117566028 (+)

Human Ortholog

TSPAN8, tetraspanin 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN8, tetraspanin 8
Synonyms

CO-029, TM4SF3
Links

HGNC:11855

NCBI Gene ID: 7103

neXtProt AC: NX_P19075

UniProt: P19075
Chr Location

12q21.1; chr12:71125085-71441898 (-) GRCh38

MGI Vertebrate Homology

Tspan8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TSPAN8
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan8

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

3
Genomic Mutations

1 involving Tspan8
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

58
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan8

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All Sequences

53
RefSeq

10
UniProt

2
CCDS

CCDS24181.1

Ensembl

ENSMUSG00000034127 (Evidence)
NCBI Gene

216350

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034127	Ensembl Gene Model \| MGI Sequence Detail	33062	C57BL/6J	± kb
transcript	ENSMUST00000035563	Ensembl \| MGI Sequence Detail	1244	Not Applicable
polypeptide	ENSMUSP00000049243	Ensembl \| MGI Sequence Detail	235	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016754 tetraspanin-8

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q8R3G9 1 site, 1 N-linked glycan (1 site)

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All nucleic 58

cDNA 58

Microarray probesets 6

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MGI:2143915, MGI:2445135

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tspan8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95831	Chr10:115653035-115653046 (+)	304 bp
Tssr3361	Chr10:115653084-115653093 (+)	352 bp
Tssr95832	Chr10:115653152-115653228 (+)	453 bp
Tssr95833	Chr10:115653232-115653247 (+)	503 bp
Tssr95834	Chr10:115653261-115653274 (+)	531 bp
Tssr95835	Chr10:115653346-115653359 (+)	616 bp
Tssr95836	Chr10:115653365-115653394 (+)	643 bp
Tssr95837	Chr10:115653404-115653419 (+)	675 bp
Tssr95838	Chr10:115653429-115653438 (+)	697 bp
Tssr95839	Chr10:115668944-115668947 (+)	16,209 bp
Tssr95840	Chr10:115682222-115682234 (+)	29,491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24