Dhrs7b MGI Mouse Gene Detail - MGI:2384931 - dehydrogenase/reductase 7B

Symbol

Dhrs7b
Name

dehydrogenase/reductase 7B
Synonyms

dehydrogenase/reductase (SDR family) member 7B, MGC:6908

Feature Type

protein coding gene
IDs

MGI:2384931
NCBI Gene: 216820
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:60721457-60749249 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.87 cM
Mapping Data

2 experiments

SNPs within 2kb

899 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384931	protein coding gene	Chr11:60721457-60751021 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018427	protein coding gene	Chr11:60752319-60784340 (+)
A/J	MGP_AJ_G0018396	protein coding gene	Chr11:58513943-58544309 (+)
AKR/J	MGP_AKRJ_G0018366	protein coding gene	Chr11:60366230-60391741 (+)
BALB/cJ	MGP_BALBcJ_G0018367	protein coding gene	Chr11:58811508-58840506 (+)
C3H/HeJ	MGP_C3HHeJ_G0018180	protein coding gene	Chr11:60309791-60340454 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018819	protein coding gene	Chr11:62676747-62708459 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016465	protein coding gene	Chr11:55655780-55686705 (+)
CAST/EiJ	MGP_CASTEiJ_G0017737	protein coding gene	Chr11:60414590-60446726 (+)
CBA/J	MGP_CBAJ_G0018154	protein coding gene	Chr11:65398358-65426294 (+)
DBA/2J	MGP_DBA2J_G0018263	protein coding gene	Chr11:58100879-58128590 (+)
FVB/NJ	MGP_FVBNJ_G0018254	protein coding gene	Chr11:57764445-57799644 (+)
LP/J	MGP_LPJ_G0018336	protein coding gene	Chr11:61328549-61357610 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018278	protein coding gene	Chr11:66463864-66490264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018860	protein coding gene	Chr11:60462239-60492917 (+)
PWK/PhJ	MGP_PWKPhJ_G0017510	protein coding gene	Chr11:58680418-58710914 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017300	protein coding gene	Chr11:60273012-60301930 (+)
WSB/EiJ	MGP_WSBEiJ_G0017789	protein coding gene	Chr11:60083940-60112528 (+)

Human Ortholog

DHRS7B, dehydrogenase/reductase 7B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHRS7B, dehydrogenase/reductase 7B
Synonyms

CGI-93, SDR32C1
Links

HGNC:24547

NCBI Gene ID: 25979

neXtProt AC: NX_Q6IAN0

UniProt: Q6IAN0
Chr Location

17p11.2; chr17:21123364-21193265 (+) GRCh38

MGI Vertebrate Homology

Dhrs7b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHRS7B
Protein SuperFamily

11-beta-HSD1
Gene Tree

Dhrs7b

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References

2 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

144
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

134
Targeted

7
Genomic Mutations

3 involving Dhrs7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

107 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap mutation die by weaning age and exhibit esophageal and gastric lesions. Thymic atrophy and muscle degeneration is also seen.

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All GO Annotations

27
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

31

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dhrs7b

ZFIN dhrs7b

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All Sequences

43
RefSeq

6
UniProt

3
CCDS

CCDS24800.1

Ensembl

ENSMUSG00000042569 (Evidence)
NCBI Gene

216820

			Length	Strain/Species	Flank
genomic	216820	NCBI Gene Model \| MGI Sequence Detail	27793	C57BL/6J	± kb
transcript	NM_001172112	RefSeq \| MGI Sequence Detail	1582	C57BL/6
polypeptide	Q99J47	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006468 dehydrogenase/reductase SDR family member 7B

(term hierarchy)
EC

1.1.-.-
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 31

cDNA 31

Microarray probesets 3

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MGI:2144655, MGI:2144658

Summaries

All 53

Diseases 2

Gene Ontology 5

Phenotypes 28
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:251809 Lodhi IJ, et al., PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Rep. 2017 Sep 19;20(12):2766-2774

TSS for Dhrs7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101923	Chr11:60721484-60721512 (+)	41 bp
Tssr101924	Chr11:60721516-60721556 (+)	79 bp
Tssr101925	Chr11:60728663-60728692 (+)	7,221 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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