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Wrap53 Gene Detail
Summary
  • Symbol
    Wrap53
  • Name
    WD repeat containing, antisense to Trp53
  • Synonyms
    MGC:28622, Wdr79
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384933
    NCBI Gene: 216853
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69452580-69471076 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    500 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384933
 protein coding gene Chr11:69452580-69471081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018537
 protein coding gene Chr11:70007524-70027856 (-)
A/J MGP_AJ_G0018505
 protein coding gene Chr11:67373392-67391911 (-)
AKR/J MGP_AKRJ_G0018474
 protein coding gene Chr11:69383139-69403019 (-)
BALB/cJ MGP_BALBcJ_G0018477
 protein coding gene Chr11:67685074-67703571 (-)
C3H/HeJ MGP_C3HHeJ_G0018290
 protein coding gene Chr11:69404224-69422718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018928
 protein coding gene Chr11:72132263-72152385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016573
 protein coding gene Chr11:64297843-64316292 (-)
CAST/EiJ MGP_CASTEiJ_G0017845
 protein coding gene Chr11:69647838-69667780 (-)
CBA/J MGP_CBAJ_G0018263
 protein coding gene Chr11:75351276-75374846 (-)
DBA/2J MGP_DBA2J_G0018372
 protein coding gene Chr11:66955951-66975076 (-)
FVB/NJ MGP_FVBNJ_G0018362
 protein coding gene Chr11:66593399-66611868 (-)
LP/J MGP_LPJ_G0018442
 protein coding gene Chr11:70578987-70599219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018385
 protein coding gene Chr11:75955727-75977096 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018970
 protein coding gene Chr11:69637409-69656789 (-)
PWK/PhJ MGP_PWKPhJ_G0017619
 protein coding gene Chr11:67604852-67624177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017409
 protein coding gene Chr11:69453486-69474409 (-)
WSB/EiJ MGP_WSBEiJ_G0017899
 protein coding gene Chr11:69311583-69330079 (-)



Homology
more
  • Human Ortholog
    WRAP53, WD repeat containing antisense to TP53
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WRAP53, WD repeat containing antisense to TP53
  • Synonyms
    DKCB3, TCAB1, WDR79
  • Links
    NCBI Gene ID: 55135
    neXtProt AC: NX_Q9BUR4
    UniProt: Q9BUR4

  • Chr Location
    17p13.1; chr17:7686071-7703502 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human WRAP53 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    37
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216853 NCBI Gene Model | MGI Sequence Detail 18497 C57BL/6J ±  kb
    transcript NM_001364769 RefSeq | MGI Sequence Detail 1934 C57BL/6  
    polypeptide Q8VC51 UniProt | EBI | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory