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Samd14 Gene Detail
Summary
  • Symbol
    Samd14
  • Name
    sterile alpha motif domain containing 14
  • Synonyms
    MGC:31049
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384945
    NCBI Gene: 217125
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94900705-94916913 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384945
 protein coding gene Chr11:94900213-94916913 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018974
 protein coding gene Chr11:97194039-97211956 (+)
A/J MGP_AJ_G0018942
 protein coding gene Chr11:93268390-93285786 (+)
AKR/J MGP_AKRJ_G0018912
 protein coding gene Chr11:96152392-96174160 (+)
BALB/cJ MGP_BALBcJ_G0018915
 protein coding gene Chr11:93741041-93757204 (+)
C3H/HeJ MGP_C3HHeJ_G0018729
 protein coding gene Chr11:96280389-96299086 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019367
 protein coding gene Chr11:100258164-100274156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016998
 protein coding gene Chr11:90755630-90772096 (+)
CAST/EiJ MGP_CASTEiJ_G0018283
 protein coding gene Chr11:97070343-97089171 (+)
CBA/J MGP_CBAJ_G0018700
 protein coding gene Chr11:104343380-104368424 (+)
DBA/2J MGP_DBA2J_G0018808
 protein coding gene Chr11:92844425-92860347 (+)
FVB/NJ MGP_FVBNJ_G0018797
 protein coding gene Chr11:92305846-92322424 (+)
LP/J MGP_LPJ_G0018878
 protein coding gene Chr11:97755099-97773290 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018824
 protein coding gene Chr11:104403229-104423089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019407
 protein coding gene Chr11:96415209-96432459 (+)
PWK/PhJ MGP_PWKPhJ_G0018054
 protein coding gene Chr11:93756132-93773532 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017843
 protein coding gene Chr11:96094808-96117425 (+)
WSB/EiJ MGP_WSBEiJ_G0018332
 protein coding gene Chr11:96333905-96349699 (+)



Homology
more
  • Human Ortholog
    SAMD14, sterile alpha motif domain containing 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMD14, sterile alpha motif domain containing 14
  • Links
    NCBI Gene ID: 201191
    neXtProt AC: NX_Q8IZD0
    UniProt: Q8IZD0

  • Chr Location
    17q21.33; chr17:50110040-50130160 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Mice homozygous for a hypomorphic allele affecting an intronic enhancer exhibit increased susceptibility to PTZ-induced anemia due to increased hematopoietic stem cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    25
  • cDNA Data
    104
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047181 Ensembl Gene Model | MGI Sequence Detail 16209 C57BL/6J ±  kb
transcript ENSMUST00000055947 Ensembl | MGI Sequence Detail 3318 Not Applicable  
polypeptide ENSMUSP00000062231 Ensembl | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    cDNA 105

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144274, MGI:2144323
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 12
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:357892 Schaefer MA, et al., Physiological and regenerative functions of sterile-alpha motif protein-14 in hematopoiesis. Exp Hematol. 2023 Sep 16;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory