Kcnk13 MGI Mouse Gene Detail - MGI:2384976 - potassium channel, subfamily K, member 13

Symbol

Kcnk13
Name

potassium channel, subfamily K, member 13
Synonyms

F730021E22Rik, LOC380778, LOC381712, THIK-1

Feature Type

protein coding gene
IDs

MGI:2384976
NCBI Gene: 217826
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr12:99930758-100028941 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 50.43 cM
Mapping Data

4 experiments

SNPs within 2kb

2994 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384976	protein coding gene	Chr12:99928132-100028941 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020014	protein coding gene	Chr12:101417616-101516211 (+)
A/J	MGP_AJ_G0019969	protein coding gene	Chr12:97611042-97708926 (+)
AKR/J	MGP_AKRJ_G0019945	protein coding gene	Chr12:100242906-100342491 (+)
BALB/cJ	MGP_BALBcJ_G0019955	protein coding gene	Chr12:97950171-98050454 (+)
C3H/HeJ	MGP_C3HHeJ_G0019757	protein coding gene	Chr12:100783766-100885261 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020404	protein coding gene	Chr12:104536748-104640989 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018018	protein coding gene	Chr12:94576303-94681037 (+)
CAST/EiJ	MGP_CASTEiJ_G0019303	protein coding gene	Chr12:95891543-95994640 (+)
CBA/J	MGP_CBAJ_G0019729	protein coding gene	Chr12:108421859-108522340 (+)
DBA/2J	MGP_DBA2J_G0019840	protein coding gene	Chr12:97042591-97140736 (+)
FVB/NJ	MGP_FVBNJ_G0019829	protein coding gene	Chr12:95756599-95858914 (+)
LP/J	MGP_LPJ_G0019916	protein coding gene	Chr12:101245997-101350445 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019871	protein coding gene	Chr12:112030724-112133504 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020433	protein coding gene	Chr12:99808764-99910422 (+)
PWK/PhJ	MGP_PWKPhJ_G0019067	protein coding gene	Chr12:91669892-91788742 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018863	protein coding gene	Chr12:93987262-94096828 (+)
WSB/EiJ	MGP_WSBEiJ_G0019357	protein coding gene	Chr12:100665224-100765739 (+)

Human Ortholog

KCNK13, potassium two pore domain channel subfamily K member 13

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNK13, potassium two pore domain channel subfamily K member 13
Synonyms

K2p13.1, THIK-1, THIK1
Links

HGNC:6275

NCBI Gene ID: 56659

neXtProt AC: NX_Q9HB14

UniProt: Q9HB14
Chr Location

14q32.11; chr14:90061994-90185853 (+) GRCh38

MGI Vertebrate Homology

Kcnk13 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: KCNK13
Gene Tree

Kcnk13

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Kcnk13
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available

Homozygous knockout reduces the surveillance activity of microglial cells in the brain.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnk13

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All Sequences

48
RefSeq

10
UniProt

3
CCDS

CCDS26106.1

Ensembl

ENSMUSG00000045404 (Evidence)
NCBI Gene

217826

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045404	Ensembl Gene Model \| MGI Sequence Detail	98184	C57BL/6J	± kb
transcript	ENSMUST00000160413	Ensembl \| MGI Sequence Detail	3061	Not Applicable
polypeptide	ENSMUSP00000123916	Ensembl \| MGI Sequence Detail	405	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002073 potassium channel subfamily K member 13

(term hierarchy)
InterPro Domains

IPR013099 Potassium channel domain

IPR003280 Two pore domain potassium channel

IPR005410 Two pore domain potassium channel, THIK
GlyGen

Q8R1P5 2 sites

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

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MGI:2145065, MGI:2686416, MGI:2686531

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 15
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345713 Rifat A, et al., Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. J Neuroinflammation. 2024 Feb 26;21(1):58

TSS for Kcnk13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114673	Chr12:99930772-99930783 (+)	20 bp
Tssr114674	Chr12:99930785-99930798 (+)	34 bp
Tssr114675	Chr12:99930929-99930956 (+)	185 bp
Tssr114676	Chr12:99931438-99931539 (+)	731 bp
Tssr114677	Chr12:99932012-99932047 (+)	1,272 bp
Tssr114678	Chr12:99932051-99932076 (+)	1,306 bp
Tssr114679	Chr12:99932186-99932205 (+)	1,438 bp
Tssr114680	Chr12:99937924-99937945 (+)	7,177 bp
Tssr114681	Chr12:99946174-99946186 (+)	15,422 bp
Tssr114682	Chr12:99965414-99965420 (+)	34,659 bp
Tssr114683	Chr12:99969945-99969962 (+)	39,196 bp
Tssr114684	Chr12:99973331-99973358 (+)	42,587 bp
Tssr114685	Chr12:99977014-99977028 (+)	46,263 bp
Tssr114686	Chr12:100010867-100010874 (+)	80,113 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24