Slc26a8 MGI Mouse Gene Detail - MGI:2385046 - solute carrier family 26, member 8

Symbol

Slc26a8
Name

solute carrier family 26, member 8
Synonyms

MGC:38861

Feature Type

protein coding gene
IDs

MGI:2385046
NCBI Gene: 224661
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:28856757-28909207 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.82 cM
Mapping Data

2 experiments

SNPs within 2kb

176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385046	protein coding gene	Chr17:28856757-28910242 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023447	protein coding gene	Chr17:28075584-28135457 (-)
A/J	MGP_AJ_G0023405	protein coding gene	Chr17:27130035-27191697 (-)
AKR/J	MGP_AKRJ_G0023370	protein coding gene	Chr17:27340188-27400324 (-)
BALB/cJ	MGP_BALBcJ_G0023410	protein coding gene	Chr17:27408815-27461339 (-)
C3H/HeJ	MGP_C3HHeJ_G0023171	protein coding gene	Chr17:27741841-27798279 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023852	protein coding gene	Chr17:29200414-29266332 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021327	protein coding gene	Chr17:24496885-24548506 (-)
CAST/EiJ	MGP_CASTEiJ_G0022672	protein coding gene	Chr17:27704425-27768718 (-)
CBA/J	MGP_CBAJ_G0023145	protein coding gene	Chr17:30274218-30342204 (-)
DBA/2J	MGP_DBA2J_G0023276	protein coding gene	Chr17:26686205-26739792 (-)
FVB/NJ	MGP_FVBNJ_G0023246	protein coding gene	Chr17:26509993-26568947 (-)
LP/J	MGP_LPJ_G0023354	protein coding gene	Chr17:28325006-28385658 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023264	protein coding gene	Chr17:29666309-29736960 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023894	protein coding gene	Chr17:27787795-27843580 (-)
PWK/PhJ	MGP_PWKPhJ_G0022422	protein coding gene	Chr17:25504336-25564581 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022240	protein coding gene	Chr17:25769277-25831613 (-)
WSB/EiJ	MGP_WSBEiJ_G0022734	protein coding gene	Chr17:27769098-27827232 (-)

Human Ortholog

SLC26A8, solute carrier family 26 member 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC26A8, solute carrier family 26 member 8
Synonyms

AZON, SPGF3, TAT1
Links

HGNC:14468

NCBI Gene ID: 116369

neXtProt AC: NX_Q96RN1

UniProt: Q96RN1
Chr Location

6p21.31; chr6:35943516-36024868 (-) GRCh38

MGI Vertebrate Homology

Slc26a8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC26A8
Gene Tree

Slc26a8

Diseases

1 with human SLC26A8 associations

				Human Disease	Mouse Models
				spermatogenic failure 3 IDs spermatogenic failure 3 DOID:0070168 OMIM:606766

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Gene trapped

15
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit male sterility associated with sperm immotility, abnormal flagella and reduced acrosomal reaction.

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

27
UniProt

5
CCDS

CCDS28582.1, CCDS70779.1

Ensembl

ENSMUSG00000036196 (Evidence)
NCBI Gene

224661

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036196	Ensembl Gene Model \| MGI Sequence Detail	52451	C57BL/6J	± kb
transcript	ENSMUST00000114764	Ensembl \| MGI Sequence Detail	3670	Not Applicable
polypeptide	ENSMUSP00000110412	Ensembl \| MGI Sequence Detail	999	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015043 testis anion transporter 1

(term hierarchy)
InterPro Domains

IPR001902 SLC26A/SulP transporter

IPR011547 SLC26A/SulP transporter domain

IPR002645 STAS domain

IPR036513 STAS domain superfamily
GlyGen

Q8R0C3 1 site

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:181151 Rode B, et al., The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation. Hum Mol Genet. 2012 Mar 15;21(6):1287-98

TSS for Slc26a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147151	Chr17:28910193-28910208 (-)	-994 bp
Tssr147150	Chr17:28910119-28910156 (-)	-931 bp
Tssr147149	Chr17:28908757-28908805 (-)	426 bp
Tssr147148	Chr17:28908742-28908752 (-)	460 bp
Tssr147147	Chr17:28908732-28908738 (-)	472 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24