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Lims2 Gene Detail
Summary
  • Symbol
    Lims2
  • Name
    LIM and senescent cell antigen like domains 2
  • Synonyms
    PINCH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385067
    NCBI Gene: 225341
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32055346-32091673 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385067
 protein coding gene Chr18:32055343-32091673 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024220
 protein coding gene Chr18:30062395-30089343 (+)
A/J MGP_AJ_G0024186
 protein coding gene Chr18:29059198-29086335 (+)
AKR/J MGP_AKRJ_G0024155
 protein coding gene Chr18:29861691-29888810 (+)
BALB/cJ MGP_BALBcJ_G0024186
 protein coding gene Chr18:29152143-29179269 (+)
C3H/HeJ MGP_C3HHeJ_G0023954
 protein coding gene Chr18:29900485-29927614 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024628
 protein coding gene Chr18:31125548-31155505 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022069
 protein coding gene Chr18:29286305-29314136 (+)
CAST/EiJ MGP_CASTEiJ_G0023429
 protein coding gene Chr18:29794834-29824988 (+)
CBA/J MGP_CBAJ_G0023922
 protein coding gene Chr18:32088137-32117626 (+)
DBA/2J MGP_DBA2J_G0024054
 protein coding gene Chr18:28732747-28760126 (+)
FVB/NJ MGP_FVBNJ_G0024020
 protein coding gene Chr18:28436343-28463469 (+)
LP/J MGP_LPJ_G0024135
 protein coding gene Chr18:30139515-30169185 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024048
 protein coding gene Chr18:33434334-33464365 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024676
 protein coding gene Chr18:29729007-29757384 (+)
PWK/PhJ MGP_PWKPhJ_G0023172
 protein coding gene Chr18:28891185-28918820 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022981
 protein coding gene Chr18:29956141-29986650 (+)
WSB/EiJ MGP_WSBEiJ_G0023492
 protein coding gene Chr18:29630582-29657692 (+)



Homology
more
  • Human Ortholog
    LIMS2, LIM zinc finger domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMS2, LIM zinc finger domain containing 2
  • Synonyms
    LGMD2W, MDRCMTT, PINCH-2, PINCH2
  • Links
    NCBI Gene ID: 55679
    neXtProt AC: NX_Q7Z4I7
    UniProt: Q7Z4I7

  • Chr Location
    2q14.3; chr2:127638381-127681786 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LIMS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with no gross abnormalities. Mice homozygous for a different targeted allele exhibit decreased fractional shortening and increased area affected following myocardial infarct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    78
  • cDNA Data
    54
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225341 NCBI Gene Model | MGI Sequence Detail 36328 C57BL/6J ±  kb
    transcript NM_001379138 RefSeq | MGI Sequence Detail 1894 C57BL/6  
    polypeptide Q91XD2 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009819 LIM and senescent cell antigen-like-containing domain protein 2
      (term hierarchy)
    • InterPro Domains
      IPR047946 LIM and senescent cell antigen-like-containing domain protein 1/2-like
      IPR047944 LIMS1/2-like, LIM domain 1
      IPR001781 Zinc finger, LIM-type
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 54
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:82868 Braun A, et al., PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003 Apr 1;284(2):239-50
    • Latest
      J:335822 Capriati M, et al., Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Sci Rep. 2023 May 17;13(1):8003
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory