Tkfc MGI Mouse Gene Detail - MGI:2385084

Symbol

Tkfc
Name

triokinase, FMN cyclase
Synonyms

Dak, MGC:28742

Feature Type

protein coding gene
IDs

MGI:2385084
NCBI Gene: 225913
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:10565155-10583018 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.60 cM
Mapping Data

1 experiment

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385084	protein coding gene	Chr19:10565153-10583257 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024851	protein coding gene	Chr19:7942160-7954218 (-)
A/J	MGP_AJ_G0024819	protein coding gene	Chr19:7403138-7415195 (-)
AKR/J	MGP_AKRJ_G0024794	protein coding gene	Chr19:7695750-7707807 (-)
BALB/cJ	MGP_BALBcJ_G0024819	protein coding gene	Chr19:7445995-7458052 (-)
C3H/HeJ	MGP_C3HHeJ_G0024585	protein coding gene	Chr19:7575693-7587750 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025267	protein coding gene	Chr19:8301357-8314567 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022694	protein coding gene	Chr19:7821001-7833905 (-)
CAST/EiJ	MGP_CASTEiJ_G0024058	protein coding gene	Chr19:7231374-7245909 (-)
CBA/J	MGP_CBAJ_G0024559	protein coding gene	Chr19:8345962-8358019 (-)
DBA/2J	MGP_DBA2J_G0024686	protein coding gene	Chr19:7412987-7425044 (-)
FVB/NJ	MGP_FVBNJ_G0024653	protein coding gene	Chr19:7457423-7471050 (-)
LP/J	MGP_LPJ_G0024773	protein coding gene	Chr19:7905563-7917621 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024680	protein coding gene	Chr19:8249111-8261168 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025315	protein coding gene	Chr19:7714175-7726233 (-)
PWK/PhJ	MGP_PWKPhJ_G0023803	protein coding gene	Chr19:6855672-6867804 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023608	protein coding gene	Chr19:6891884-6904410 (-)
WSB/EiJ	MGP_WSBEiJ_G0024120	protein coding gene	Chr19:7598641-7611927 (-)

Human Ortholog

TKFC, triokinase and FMN cyclase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TKFC, triokinase and FMN cyclase
Synonyms

DAK, NET45, TKFCD
Links

HGNC:24552

NCBI Gene ID: 26007

neXtProt AC: NX_Q3LXA3

UniProt: Q3LXA3
Chr Location

11q12.2; chr11:61333220-61353426 (+) GRCh38

MGI Vertebrate Homology

Tkfc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TKFC
Gene Tree

Tkfc

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

12
Targeted

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tkfc

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All Sequences

59
RefSeq

18
UniProt

4
CCDS

CCDS37914.1

Ensembl

ENSMUSG00000034371 (Evidence)
NCBI Gene

225913

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034371	Ensembl Gene Model \| MGI Sequence Detail	17864	C57BL/6J	± kb
transcript	ENSMUST00000236607	Ensembl \| MGI Sequence Detail	2516	Not Applicable
polypeptide	ENSMUSP00000157520	Ensembl \| MGI Sequence Detail	578	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006270 triokinase/FMN cyclase

(term hierarchy)
EC

2.7.1.28, 2.7.1.29, 4.6.1.15
InterPro Domains

IPR004006 DhaK domain

IPR004007 DhaL domain

IPR036117 DhaL domain superfamily

IPR012734 Dihydroxyacetone kinase

IPR050861 Dihydroxyacetone Kinase (DAK)
GlyGen

Q8VC30 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 24

Microarray probesets 2

Summaries

All 37

Gene Ontology 13

Phenotypes 10
Earliest

J:321828 Massillon D, et al., Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 ( Pt 1):123-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tkfc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158207	Chr19:10583232-10583279 (-)	-238 bp
Tssr158206	Chr19:10582831-10582834 (-)	185 bp
Tssr158205	Chr19:10582774-10582830 (-)	216 bp
Tssr158204	Chr19:10582729-10582769 (-)	269 bp
Tssr158203	Chr19:10581758-10581761 (-)	1,258 bp
Tssr158202	Chr19:10581717-10581731 (-)	1,294 bp
Tssr158201	Chr19:10581680-10581701 (-)	1,327 bp
Tssr158200	Chr19:10581668-10581679 (-)	1,344 bp
Tssr158199	Chr19:10570539-10570550 (-)	12,473 bp
Tssr158198	Chr19:10569887-10569916 (-)	13,116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24