Lzts2 MGI Mouse Gene Detail - MGI:2385095 - leucine zipper, putative tumor suppressor 2

Symbol

Lzts2
Name

leucine zipper, putative tumor suppressor 2
Synonyms

MGC:7094, mKIAA1813

Feature Type

protein coding gene
IDs

MGI:2385095
NCBI Gene: 226154
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:45003615-45015554 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.20 cM
Mapping Data

2 experiments

SNPs within 2kb

261 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385095	protein coding gene	Chr19:45002853-45015554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025181	protein coding gene	Chr19:44554171-44572121 (+)
A/J	MGP_AJ_G0025158	protein coding gene	Chr19:42413622-42425620 (+)
AKR/J	MGP_AKRJ_G0025126	protein coding gene	Chr19:43774112-43786005 (+)
BALB/cJ	MGP_BALBcJ_G0025152	protein coding gene	Chr19:42463188-42475646 (+)
C3H/HeJ	MGP_C3HHeJ_G0024912	protein coding gene	Chr19:43924731-43939209 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025595	protein coding gene	Chr19:45643906-45659929 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023009	protein coding gene	Chr19:41680323-41692508 (+)
CAST/EiJ	MGP_CASTEiJ_G0024377	protein coding gene	Chr19:43673664-43689644 (+)
CBA/J	MGP_CBAJ_G0024892	protein coding gene	Chr19:47961405-47979565 (+)
DBA/2J	MGP_DBA2J_G0025024	protein coding gene	Chr19:42230691-42244687 (+)
FVB/NJ	MGP_FVBNJ_G0024985	protein coding gene	Chr19:41998511-42011170 (+)
LP/J	MGP_LPJ_G0025110	protein coding gene	Chr19:44493316-44511653 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025016	protein coding gene	Chr19:47347231-47363173 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025653	protein coding gene	Chr19:43849447-43862769 (+)
PWK/PhJ	MGP_PWKPhJ_G0024126	protein coding gene	Chr19:42137826-42151264 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023930	protein coding gene	Chr19:42546191-42557962 (+)
WSB/EiJ	MGP_WSBEiJ_G0024447	protein coding gene	Chr19:43993316-44008094 (+)

Human Ortholog

LZTS2, leucine zipper tumor suppressor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LZTS2, leucine zipper tumor suppressor 2
Synonyms

LAPSER1
Links

HGNC:29381

NCBI Gene ID: 84445

neXtProt AC: NX_Q9BRK4

UniProt: Q9BRK4
Chr Location

10q24.31; chr10:100996588-101007836 (+) GRCh38

MGI Vertebrate Homology

Lzts2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LZTS2
Gene Tree

Lzts2

Diseases

1 with Lzts2 mouse models

Human Disease

Mouse Models

urinary system disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
3 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

1
Gene trapped

12
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display defects in urinary tract development.

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All GO Annotations

32
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

30
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lzts2

ZFIN lzts2a

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All Sequences

89
RefSeq

16
UniProt

5
CCDS

CCDS29855.1

Ensembl

ENSMUSG00000035342 (Evidence)
NCBI Gene

226154

			Length	Strain/Species	Flank
genomic	226154	NCBI Gene Model \| MGI Sequence Detail	11940	C57BL/6J	± kb
transcript	NM_145503	RefSeq \| MGI Sequence Detail	2825	C57BL/6
polypeptide	Q91YU6	UniProt \| EBI \| MGI Sequence Detail	671	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031890 leucine zipper putative tumor suppressor 2

(term hierarchy)
InterPro Domains

IPR045329 Leucine zipper putative tumor suppressor

IPR028597 Leucine zipper putative tumour suppressor 2

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All nucleic 16

cDNA 13

Other 3

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 9
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Lzts2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156651	Chr19:45003434-45003445 (+)	-175 bp
Tssr156652	Chr19:45003607-45003626 (+)	2 bp
Tssr156653	Chr19:45003637-45003663 (+)	35 bp
Tssr156654	Chr19:45003671-45003687 (+)	64 bp
Tssr156655	Chr19:45005376-45005381 (+)	1,764 bp
Tssr156656	Chr19:45005868-45005924 (+)	2,281 bp
Tssr5531	Chr19:45006071-45006113 (+)	2,477 bp
Tssr156657	Chr19:45006128-45006141 (+)	2,520 bp
Tssr156658	Chr19:45006490-45006502 (+)	2,881 bp
Tssr156659	Chr19:45006553-45006592 (+)	2,958 bp
Tssr156660	Chr19:45006593-45006636 (+)	3,000 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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