Farp2 MGI Mouse Gene Detail - MGI:2385126 - FERM, RhoGEF and pleckstrin domain protein 2

Symbol

Farp2
Name

FERM, RhoGEF and pleckstrin domain protein 2
Synonyms

D030026M03Rik, Fir

Feature Type

protein coding gene
IDs

MGI:2385126
NCBI Gene: 227377
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:93439826-93549698 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.24 cM
Mapping Data

3 experiments

SNPs within 2kb

2609 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385126	protein coding gene	Chr1:93439801-93549698 (+)
129S1/SvImJ	ENSMUSG00200037658	protein coding gene	Chr1:90657011-90766904 (+)
A/J	ENSMUSG00195032006	protein coding gene	Chr1:90215946-90325843 (+)
AKR/J	ENSMUSG00220044372	protein coding gene	Chr1:90370663-90480556 (+)
BALB/cJ	ENSMUSG00180014928	protein coding gene	Chr1:90533145-90643051 (+)
C3H/HeJ	ENSMUSG00175001044	protein coding gene	Chr1:90411042-90520964 (+)
C57BL/6NJ	ENSMUSG00215030804	protein coding gene	Chr1:90342344-90452241 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014458	protein coding gene	Chr1:85986214-86090569 (+)
CAST/EiJ	ENSTCUG00005006887	protein coding gene	Chr1:89992279-90101906 (+)
CBA/J	ENSMUSG00210012226	protein coding gene	Chr1:90256259-90366158 (+)
DBA/2J	ENSMUSG00185013173	protein coding gene	Chr1:94729272-94839166 (+)
FVB/NJ	ENSMUSG00205024578	protein coding gene	Chr1:89665653-89775544 (+)
JF1/MsJ	ENSUMUG00000014377	protein coding gene	Chr1:93467480-93577105 (+)
LP/J	ENSMUSG00230020788	protein coding gene	Chr1:93993107-94102996 (+)
NOD/ShiLtJ	ENSMUSG00190021798	protein coding gene	Chr1:90300878-90410764 (+)
NZO/HlLtJ	ENSMUSG00225002940	protein coding gene	Chr1:97891220-98001086 (+)
PWK/PhJ	ENSLUMG00010040623	protein coding gene	Chr1:89855217-89963614 (+)
SPRET/EiJ	ENSMSPG00010000684	protein coding gene	Chr1:91891564-92001068 (+)
WSB/EiJ	ENSIUOG00005035268	protein coding gene	Chr1:89952618-90062676 (+)

Human Ortholog

FARP2, FERM, ARH/RhoGEF and pleckstrin domain protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FARP2, FERM, ARH/RhoGEF and pleckstrin domain protein 2
Synonyms

FIR, FRG, PLEKHC3
Links

HGNC:16460

NCBI Gene ID: 9855

UniProt: O94887
Chr Location

2q37.3; chr2:241356264-241494847 (+) GRCh38

MGI Vertebrate Homology

Farp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FARP2
Gene Tree

Farp2

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Farp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

91
cDNA Data

28
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FARP2

Xenbase farp2

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS15191.1

Ensembl

ENSMUSG00000034066 (Evidence)
NCBI Gene

227377

			Length	Strain/Species	Flank
genomic	227377	NCBI Gene Model \| MGI Sequence Detail	109873	C57BL/6J	± kb
transcript	NM_145519	RefSeq \| MGI Sequence Detail	3929	C57BL/6
polypeptide	Q91VS8	UniProt \| EBI \| MGI Sequence Detail	1065	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007344 FERM, ARHGEF and pleckstrin domain-containing protein 2

(term hierarchy)
PDB

4GYV, 4GZU, 6D2K
InterPro Domains

IPR019749 Band 4.1 domain

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR000798 Ezrin/radixin/moesin-like

IPR041788 FARP1/FARP2/FRMD7, FERM domain C-lobe

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR014847 FERM adjacent

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR051835 RAC1-specific guanine nucleotide exchange factor

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q91VS8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 29

Microarray probesets 4

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MGI:2138267, MGI:2444756

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Farp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8185	Chr1:93439810-93439847 (+)	3 bp
Tssr8186	Chr1:93439850-93439878 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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