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Lrrc26 Gene Detail
Summary
  • Symbol
    Lrrc26
  • Name
    leucine rich repeat containing 26
  • Synonyms
    MGC:37548, MGC:37592, MGC:6965
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385129
    NCBI Gene: 227618
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25179927-25181192 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385129
 protein coding gene Chr2:25179923-25181205 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025437
 protein coding gene Chr2:23157786-23159051 (+)
A/J MGP_AJ_G0025414
 protein coding gene Chr2:22269207-22270472 (+)
AKR/J MGP_AKRJ_G0025384
 protein coding gene Chr2:23014657-23015922 (+)
BALB/cJ MGP_BALBcJ_G0025410
 protein coding gene Chr2:22380396-22381661 (+)
C3H/HeJ MGP_C3HHeJ_G0025171
 protein coding gene Chr2:22940378-22941643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025854
 protein coding gene Chr2:23892512-23893777 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023265
 protein coding gene Chr2:21185373-21186640 (+)
CAST/EiJ MGP_CASTEiJ_G0024635
 protein coding gene Chr2:22823849-22825114 (+)
CBA/J MGP_CBAJ_G0025149
 protein coding gene Chr2:24729528-24730793 (+)
DBA/2J MGP_DBA2J_G0025282
 protein coding gene Chr2:22110807-22112072 (+)
FVB/NJ MGP_FVBNJ_G0025244
 protein coding gene Chr2:21851790-21853055 (+)
LP/J MGP_LPJ_G0025368
 protein coding gene Chr2:23102325-23103590 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025275
 protein coding gene Chr2:24930413-24931678 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025913
 protein coding gene Chr2:22960694-22961959 (+)
PWK/PhJ MGP_PWKPhJ_G0024383
 protein coding gene Chr2:21924007-21925272 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024183
 protein coding gene Chr2:23115370-23116635 (+)
WSB/EiJ MGP_WSBEiJ_G0024703
 protein coding gene Chr2:23031219-23032484 (+)



Homology
more
  • Human Ortholog
    LRRC26, leucine rich repeat containing 26
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC26, leucine rich repeat containing 26
  • Synonyms
    bA350O14.10, CAPC
  • Links
    NCBI Gene ID: 389816
    neXtProt AC: NX_Q2I0M4
    UniProt: Q2I0M4

  • Chr Location
    9q34.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product is part of BK ion channels in secretory epithelial cells. Homozygous knockout results in significantly reduced K+ efflux from salivary glands.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026961 Ensembl Gene Model | MGI Sequence Detail 1266 C57BL/6J ±  kb
    transcript ENSMUST00000028337 Ensembl | MGI Sequence Detail 1190 Not Applicable  
    polypeptide ENSMUSP00000028337 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032092 leucine-rich repeat-containing protein 26
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR051432 Voltage and calcium-activated potassium channel auxiliary protein
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:300474 Gonzalez-Perez V, et al., Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2019149118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory