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Sh3glb2 Gene Detail
Summary
  • Symbol
    Sh3glb2
  • Name
    SH3-domain GRB2-like endophilin B2
  • Synonyms
    mKIAA1848
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385131
    NCBI Gene: 227700
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30234821-30249349 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385131
 protein coding gene Chr2:30234789-30249380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025565
 protein coding gene Chr2:28570243-28584715 (-)
A/J MGP_AJ_G0025543
 protein coding gene Chr2:27430310-27444825 (-)
AKR/J MGP_AKRJ_G0025512
 protein coding gene Chr2:28362022-28378284 (-)
BALB/cJ MGP_BALBcJ_G0025539
 protein coding gene Chr2:27553709-27572269 (-)
C3H/HeJ MGP_C3HHeJ_G0025300
 protein coding gene Chr2:28293956-28309228 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025984
 protein coding gene Chr2:29506000-29520488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023392
 protein coding gene Chr2:26208259-26222931 (-)
CAST/EiJ MGP_CASTEiJ_G0024762
 protein coding gene Chr2:28189768-28204267 (-)
CBA/J MGP_CBAJ_G0025277
 protein coding gene Chr2:30509737-30524222 (-)
DBA/2J MGP_DBA2J_G0025410
 protein coding gene Chr2:27219020-27234030 (-)
FVB/NJ MGP_FVBNJ_G0025373
 protein coding gene Chr2:27038137-27053314 (-)
LP/J MGP_LPJ_G0025496
 protein coding gene Chr2:28475726-28490067 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025403
 protein coding gene Chr2:30389987-30407115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026042
 protein coding gene Chr2:28278636-28293116 (-)
PWK/PhJ MGP_PWKPhJ_G0024509
 protein coding gene Chr2:27059382-27073877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024309
 protein coding gene Chr2:28395624-28410099 (-)
WSB/EiJ MGP_WSBEiJ_G0024830
 protein coding gene Chr2:28405832-28420318 (-)



Homology
more
  • Human Ortholog
    SH3GLB2, SH3 domain containing GRB2 like, endophilin B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3GLB2, SH3 domain containing GRB2 like, endophilin B2
  • Synonyms
    PP6569, PP9455, RRIG1
  • Links
    NCBI Gene ID: 56904
    neXtProt AC: NX_Q9NR46
    UniProt: Q9NR46

  • Chr Location
    9q34.11; chr9:129007036-129028331 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at normal expected Mendelian ratios and appear indistinguishable from wild-type controls. In vitro, mouse embryonic fibroblasts exhibit impaired endosomal trafficking, autophagic flux, and influenza A viral RNA nuclear entry and replication.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    25
  • cDNA Data
    99
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026860 Ensembl Gene Model | MGI Sequence Detail 14529 C57BL/6J ±  kb
transcript ENSMUST00000113621 Ensembl | MGI Sequence Detail 1851 Not Applicable  
polypeptide ENSMUSP00000109251 Ensembl | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    cDNA 99

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
  • Latest
    J:246421 Serfass JM, et al., Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. J Biol Chem. 2017 Jun 16;292(24):10097-10111
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory