Rabgap1 MGI Mouse Gene Detail - MGI:2385139 - RAB GTPase activating protein 1

Symbol

Rabgap1
Name

RAB GTPase activating protein 1
Synonyms

Gapcena

Feature Type

protein coding gene
IDs

MGI:2385139
NCBI Gene: 227800
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:37333291-37456466 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 24.19 cM
Mapping Data

1 experiment

SNPs within 2kb

1981 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385139	protein coding gene	Chr2:37333274-37463653 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025696	protein coding gene	Chr2:36133839-36267845 (+)
A/J	MGP_AJ_G0025673	protein coding gene	Chr2:34658646-34784908 (+)
AKR/J	MGP_AKRJ_G0025643	protein coding gene	Chr2:35807990-35942336 (+)
BALB/cJ	MGP_BALBcJ_G0025668	protein coding gene	Chr2:34723374-34847174 (+)
C3H/HeJ	MGP_C3HHeJ_G0025429	protein coding gene	Chr2:35733394-35859008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026114	protein coding gene	Chr2:37176289-37302410 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023519	protein coding gene	Chr2:33332793-33458103 (+)
CAST/EiJ	MGP_CASTEiJ_G0024892	protein coding gene	Chr2:35637943-35770204 (+)
CBA/J	MGP_CBAJ_G0025408	protein coding gene	Chr2:38571148-38701087 (+)
DBA/2J	MGP_DBA2J_G0025540	protein coding gene	Chr2:34404536-34528636 (+)
FVB/NJ	MGP_FVBNJ_G0025502	protein coding gene	Chr2:34285073-34409727 (+)
LP/J	MGP_LPJ_G0025627	protein coding gene	Chr2:36029396-36155377 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025533	protein coding gene	Chr2:38166779-38298383 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026172	protein coding gene	Chr2:35687640-35822366 (+)
PWK/PhJ	MGP_PWKPhJ_G0024634	protein coding gene	Chr2:34298803-34424857 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024439	protein coding gene	Chr2:35803892-35931775 (+)
WSB/EiJ	MGP_WSBEiJ_G0024960	protein coding gene	Chr2:35878591-36003988 (+)

Human Ortholog

RABGAP1, RAB GTPase activating protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RABGAP1, RAB GTPase activating protein 1
Synonyms

GAPCENA, TBC1D11
Links

HGNC:17155

NCBI Gene ID: 23637

neXtProt AC: NX_Q9Y3P9

UniProt: Q9Y3P9
Chr Location

9q33.2-q33.3; chr9:122931671-123104866 (+) GRCh38

MGI Vertebrate Homology

Rabgap1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RABGAP1
Gene Tree

Rabgap1

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Phenotype Summary

23 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Endonuclease-mediated

1
Gene trapped

42
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

84
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rabgap1

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All Sequences

71
RefSeq

17
UniProt

4
CCDS

CCDS16002.1, CCDS16003.1

Ensembl

ENSMUSG00000035437 (Evidence)
NCBI Gene

227800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035437	Ensembl Gene Model \| MGI Sequence Detail	123176	C57BL/6J	± kb
transcript	ENSMUST00000112920	Ensembl \| MGI Sequence Detail	4847	Not Applicable
polypeptide	ENSMUSP00000108542	Ensembl \| MGI Sequence Detail	1064	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013650 Rab GTPase-activating protein 1

(term hierarchy)
InterPro Domains

IPR022164 Kinesin-like

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR050302 Rab GTPase-activating TBC domain-containing protein
GlyGen

A2AWA9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 88

cDNA 87

Primer pair 1

Microarray probesets 5

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 13
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rabgap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17522	Chr2:37333285-37333351 (+)	27 bp
Tssr17523	Chr2:37333354-37333371 (+)	72 bp
Tssr17524	Chr2:37342228-37342242 (+)	8,944 bp
Tssr17525	Chr2:37342243-37342298 (+)	8,980 bp
Tssr17526	Chr2:37395408-37395412 (+)	62,119 bp
Tssr17529	Chr2:37422787-37422791 (+)	89,498 bp
Tssr17530	Chr2:37441398-37441401 (+)	108,109 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24