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Mettl8 Gene Detail
Summary
  • Symbol
    Mettl8
  • Name
    methyltransferase 8, methylcytidine
  • Synonyms
    MGC:67805, MGC:7995, TIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385142
    NCBI Gene: 228019
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70794905-70885927 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2726 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385142
 protein coding gene Chr2:70794902-70886729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025817
 protein coding gene Chr2:71039310-71130405 (-)
A/J MGP_AJ_G0025794
 protein coding gene Chr2:68272104-68364131 (-)
AKR/J MGP_AKRJ_G0025763
 protein coding gene Chr2:70131548-70228106 (-)
BALB/cJ MGP_BALBcJ_G0025789
 protein coding gene Chr2:68461483-68552884 (-)
C3H/HeJ MGP_C3HHeJ_G0025549
 protein coding gene Chr2:70346301-70442968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026236
 protein coding gene Chr2:73160968-73260884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023639
 protein coding gene Chr2:65506968-65596400 (-)
CAST/EiJ MGP_CASTEiJ_G0025013
 protein coding gene Chr2:70522648-70621412 (-)
CBA/J MGP_CBAJ_G0025529
 protein coding gene Chr2:75875152-75978561 (-)
DBA/2J MGP_DBA2J_G0025660
 protein coding gene Chr2:67902423-67992804 (-)
FVB/NJ MGP_FVBNJ_G0025623
 protein coding gene Chr2:67289771-67381692 (-)
LP/J MGP_LPJ_G0025749
 protein coding gene Chr2:70886545-70987839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025652
 protein coding gene Chr2:77882346-77982241 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026293
 protein coding gene Chr2:70222072-70319120 (-)
PWK/PhJ MGP_PWKPhJ_G0024754
 protein coding gene Chr2:67765762-67858948 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024561
 protein coding gene Chr2:70427375-70524751 (-)
WSB/EiJ MGP_WSBEiJ_G0025081
 protein coding gene Chr2:70660624-70755034 (-)



Homology
more
  • Human Ortholog
    METTL8, methyltransferase 8, tRNA N3-cytidine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL8, methyltransferase 8, tRNA N3-cytidine
  • Synonyms
    TIP
  • Links
    NCBI Gene ID: 79828
    neXtProt AC: NX_Q9H825
    UniProt: Q9H825

  • Chr Location
    2q31.1; chr2:171315746-171434802 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of mRNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    16
  • cDNA Data
    5
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041975 Ensembl Gene Model | MGI Sequence Detail 91023 C57BL/6J ±  kb
transcript ENSMUST00000112186 Ensembl | MGI Sequence Detail 2347 Not Applicable  
polypeptide ENSMUSP00000107804 Ensembl | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010354 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR013216 Methyltransferase type 11
    IPR013217 Methyltransferase type 12
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR026113 tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:334113 Zhang F, et al., Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification. Cell Stem Cell. 2023 Mar 2;30(3):300-311.e11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory