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Pabpc4 Gene Detail
Summary
  • Symbol
    Pabpc4
  • Name
    poly(A) binding protein, cytoplasmic 4
  • Synonyms
    MGC:11665, MGC:6685
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385206
    NCBI Gene: 230721
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123172722-123192718 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385206
 protein coding gene Chr4:123156144-123192718 (+)
129S1/SvImJ ENSMUSG00200013960
 protein coding gene Chr4:116612260-116628620 (+)
A/J ENSMUSG00195028317
 protein coding gene Chr4:117942710-117959174 (+)
AKR/J ENSMUSG00220021994
 protein coding gene Chr4:116910731-116927170 (+)
BALB/cJ ENSMUSG00180041326
 protein coding gene Chr4:115580877-115597333 (+)
C3H/HeJ ENSMUSG00175024839
 protein coding gene Chr4:116593919-116610373 (+)
C57BL/6NJ ENSMUSG00215021165
 protein coding gene Chr4:118087906-118104248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026435
 protein coding gene Chr4:113046400-113081925 (+)
CAST/EiJ ENSTCUG00005044746
 protein coding gene Chr4:117450633-117466553 (+)
CBA/J ENSMUSG00210052507
 protein coding gene Chr4:116200243-116216698 (+)
DBA/2J ENSMUSG00185046239
 protein coding gene Chr4:117755458-117771909 (+)
FVB/NJ ENSMUSG00205011205
 protein coding gene Chr4:115963975-115980193 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230044353
 protein coding gene Chr4:121550354-121566714 (+)
NOD/ShiLtJ ENSMUSG00190027820
 protein coding gene Chr4:115957480-115973966 (+)
NZO/HlLtJ ENSMUSG00225015626
 protein coding gene Chr4:127457712-127474150 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010030842
 protein coding gene Chr4:117538097-117553365 (+)
WSB/EiJ ENSIUOG00005044577
 protein coding gene Chr4:115825416-115841628 (+)



Homology
more
  • Human Ortholog
    PABPC4, poly(A) binding protein cytoplasmic 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PABPC4, poly(A) binding protein cytoplasmic 4
  • Synonyms
    APP-1, APP1, iPABP, PABP4
  • Links
    NCBI Gene ID: 8761
    UniProt: Q13310

  • Chr Location
    1p34.3; chr1:39560709-39576868 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    25
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230721 NCBI Gene Model | MGI Sequence Detail 19997 C57BL/6J ±  kb
    transcript NM_130881 RefSeq | MGI Sequence Detail 3112 C57BL/6  
    polypeptide NP_570951 RefSeq | MGI Sequence Detail 660 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR036053 PABC (PABP) domain
      IPR034364 PABP, RNA recognition motif 1
      IPR045305 PABP, RNA recognition motif 2
      IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
      IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryotic-type
    • GlyGen
      Q6PHQ9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 12
      Primer pair 1
      Antibodies 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory