Hdac11 MGI Mouse Gene Detail - MGI:2385252

Symbol

Hdac11
Name

histone deacetylase 11
Synonyms

MGC:27683

Feature Type

protein coding gene
IDs

MGI:2385252
NCBI Gene: 232232
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:91133652-91151674 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 40.38 cM
Mapping Data

1 experiment

SNPs within 2kb

575 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385252	protein coding gene	Chr6:91133647-91151674 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031043	protein coding gene	Chr6:92737843-92759676 (+)
A/J	MGP_AJ_G0031011	protein coding gene	Chr6:89205325-89223285 (+)
AKR/J	MGP_AKRJ_G0030943	protein coding gene	Chr6:91682967-91701187 (+)
BALB/cJ	MGP_BALBcJ_G0031023	protein coding gene	Chr6:89146113-89164246 (+)
C3H/HeJ	MGP_C3HHeJ_G0030685	protein coding gene	Chr6:92738909-92756843 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031482	protein coding gene	Chr6:95157414-95178063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028650	protein coding gene	Chr6:87186015-87204601 (+)
CAST/EiJ	MGP_CASTEiJ_G0030130	protein coding gene	Chr6:91799803-91818430 (+)
CBA/J	MGP_CBAJ_G0030709	protein coding gene	Chr6:98688988-98706833 (+)
DBA/2J	MGP_DBA2J_G0030862	protein coding gene	Chr6:88391291-88409235 (+)
FVB/NJ	MGP_FVBNJ_G0030816	protein coding gene	Chr6:87596702-87615588 (+)
LP/J	MGP_LPJ_G0030942	protein coding gene	Chr6:92699030-92718800 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030850	protein coding gene	Chr6:102765892-102783901 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031509	protein coding gene	Chr6:91526730-91545680 (+)
PWK/PhJ	MGP_PWKPhJ_G0029846	protein coding gene	Chr6:87338021-87356475 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029675	protein coding gene	Chr6:90434963-90452862 (+)
WSB/EiJ	MGP_WSBEiJ_G0030214	protein coding gene	Chr6:91986690-92005463 (+)

Human Ortholog

HDAC11, histone deacetylase 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDAC11, histone deacetylase 11
Synonyms

HD11
Links

HGNC:19086

NCBI Gene ID: 79885

neXtProt AC: NX_Q96DB2

UniProt: Q96DB2
Chr Location

3p25.1; chr3:13479724-13506424 (+) GRCh38

MGI Vertebrate Homology

Hdac11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HDAC11
Gene Tree

Hdac11

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

7
Spontaneous

1
Targeted

6
Genomic Mutations

1 involving Hdac11
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

15
cDNA Data

59
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hdac11

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All Sequences

54
RefSeq

6
UniProt

5
CCDS

CCDS20366.1

Ensembl

ENSMUSG00000034245 (Evidence)
NCBI Gene

232232

			Length	Strain/Species	Flank
genomic	232232	NCBI Gene Model \| MGI Sequence Detail	18023	C57BL/6J	± kb
transcript	NM_144919	RefSeq \| MGI Sequence Detail	2494	C57BL/6
polypeptide	Q91WA3	UniProt \| EBI \| MGI Sequence Detail	347	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008480 histone deacetylase 11

(term hierarchy)
EC

3.5.1.98
InterPro Domains

IPR044150 Histone deacetylase 11

IPR050284 Histone deacetylase and polyamine deacetylase

IPR023801 Histone deacetylase domain

IPR037138 Histone deacetylase domain superfamily

IPR000286 Histone deacetylase family

IPR023696 Ureohydrolase domain superfamily

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All nucleic 62

cDNA 59

Primer pair 3

Microarray probesets 3

Summaries

All 73

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 32
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hdac11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57697	Chr6:91133697-91133720 (+)	57 bp
Tssr57698	Chr6:91133722-91133747 (+)	83 bp
Tssr57699	Chr6:91133754-91133809 (+)	130 bp
Tssr57700	Chr6:91134065-91134081 (+)	421 bp
Tssr57701	Chr6:91134233-91134244 (+)	587 bp
Tssr57702	Chr6:91134355-91134373 (+)	712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24