Dkk4 MGI Mouse Gene Detail - MGI:2385299 - dickkopf WNT signaling pathway inhibitor 4

Symbol

Dkk4
Name

dickkopf WNT signaling pathway inhibitor 4
Synonyms

MGC:25705

Feature Type

protein coding gene
IDs

MGI:2385299
NCBI Gene: 234130
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:23114059-23117563 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 11.42 cM
Mapping Data

1 experiment

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385299	protein coding gene	Chr8:23113701-23117563 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033455	protein coding gene	Chr8:20479875-20483560 (+)
A/J	MGP_AJ_G0033435	protein coding gene	Chr8:19815703-19819219 (+)
AKR/J	MGP_AKRJ_G0033360	protein coding gene	Chr8:20464190-20469123 (+)
BALB/cJ	MGP_BALBcJ_G0033431	protein coding gene	Chr8:19939320-19942805 (+)
C3H/HeJ	MGP_C3HHeJ_G0033145	protein coding gene	Chr8:20664763-20670400 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033947	protein coding gene	Chr8:21348550-21353392 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030900	protein coding gene	Chr8:17144049-17147500 (+)
CAST/EiJ	MGP_CASTEiJ_G0032471	protein coding gene	Chr8:20081051-20084512 (+)
CBA/J	MGP_CBAJ_G0033120	protein coding gene	Chr8:22201459-22206048 (+)
DBA/2J	MGP_DBA2J_G0033275	protein coding gene	Chr8:19781175-19784623 (+)
FVB/NJ	MGP_FVBNJ_G0033219	protein coding gene	Chr8:19580880-19585215 (+)
LP/J	MGP_LPJ_G0033364	protein coding gene	Chr8:20477712-20481189 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033262	protein coding gene	Chr8:21798453-21801968 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033966	protein coding gene	Chr8:20371888-20376326 (+)
PWK/PhJ	MGP_PWKPhJ_G0032183	protein coding gene	Chr8:19368449-19371980 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032016	protein coding gene	Chr8:19751599-19755117 (+)
WSB/EiJ	MGP_WSBEiJ_G0032587	protein coding gene	Chr8:20574141-20578421 (+)

Human Ortholog

DKK4, dickkopf WNT signaling pathway inhibitor 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DKK4, dickkopf WNT signaling pathway inhibitor 4
Synonyms

DKK-4
Links

HGNC:2894

NCBI Gene ID: 27121

neXtProt AC: NX_Q9UBT3

UniProt: Q9UBT3
Chr Location

8p11.21; chr8:42374063-42391322 (-) GRCh38

MGI Vertebrate Homology

Dkk4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DKK4
Gene Tree

Dkk4

less

Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional ready allele are phenotypically normal.

less

All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

171
cDNA Data

10
Literature Summary

42

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

28
RefSeq

4
UniProt

1
CCDS

CCDS22180.1

Ensembl

ENSMUSG00000031535 (Evidence)
NCBI Gene

234130

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031535	Ensembl Gene Model \| MGI Sequence Detail	3505	C57BL/6J	± kb
transcript	ENSMUST00000033936	Ensembl \| MGI Sequence Detail	1315	Not Applicable
polypeptide	ENSMUSP00000033936	Ensembl \| MGI Sequence Detail	221	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000006502 dickkopf-related protein 4

(term hierarchy)
InterPro Domains

IPR006796 Dickkopf, N-terminal cysteine-rich

IPR048500 Dickkopf-related protein 1/2/4, C-terminal subdomain 1

IPR048499 Dickkopf-related protein 1/2/4, C-terminal subdomain 2

IPR039863 Dickkopf related protein 1-4

IPR047299 Dickkopf-related protein 4, second cysteine-rich domain

less

All nucleic 24

cDNA 10

Primer pair 8

Other 6

Microarray probesets 2

Summaries

All 70

Developmental Gene Expression 42

Gene Ontology 4

Phenotypes 12
Earliest

J:94639 Diep DB, et al., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain. Brain Res Dev Brain Res. 2004 Nov 25;153(2):261-70
Latest

J:350462 Papagno V, et al., Wnt target gene Ascl4 is dispensable for skin appendage development. Int J Dev Biol. 2024 May 13;

TSS for Dkk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76588	Chr8:23114035-23114039 (+)	-22 bp
Tssr2514	Chr8:23115536-23115539 (+)	1,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24