Slc22a26 MGI Mouse Gene Detail - MGI:2385316 - solute carrier family 22 (organic cation transporter), member 26

Symbol

Slc22a26
Name

solute carrier family 22 (organic cation transporter), member 26
Synonyms

BC014805

Feature Type

protein coding gene
IDs

MGI:2385316
NCBI Gene: 236149
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:7758406-7780032 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.35 cM
Mapping Data

1 experiment

SNPs within 2kb

512 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385316	protein coding gene	Chr19:7757459-7780032 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024798	protein coding gene	Chr19:4923515-4957238 (-)
A/J	MGP_AJ_G0024765	protein coding gene	Chr19:4587114-4608740 (-)
AKR/J	MGP_AKRJ_G0024738	protein coding gene	Chr19:4694564-4728562 (-)
BALB/cJ	MGP_BALBcJ_G0024765	protein coding gene	Chr19:4653943-4675569 (-)
C3H/HeJ	MGP_C3HHeJ_G0024532	protein coding gene	Chr19:4819291-4844446 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025211	protein coding gene	Chr19:5028120-5049746 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0024005	protein coding gene	Chr19:4736031-4762271 (-)
CBA/J	MGP_CBAJ_G0024505	protein coding gene	Chr19:5119491-5143286 (-)
DBA/2J	MGP_DBA2J_G0024632	protein coding gene	Chr19:4499868-4522113 (-)
FVB/NJ	MGP_FVBNJ_G0024597	protein coding gene	Chr19:4560932-4582566 (-)
LP/J	MGP_LPJ_G0024718	protein coding gene	Chr19:4789790-4814451 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024627	protein coding gene	Chr19:5005942-5027975 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025259	protein coding gene	Chr19:4866270-4890379 (-)
PWK/PhJ	MGP_PWKPhJ_G0023751	protein coding gene	Chr19:4571078-4596574 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023555	protein coding gene	Chr19:4626630-4671568 (-)
WSB/EiJ	MGP_WSBEiJ_G0024067	protein coding gene	Chr19:4749808-4772620 (-)

Human Ortholog

SLC22A25, solute carrier family 22 member 25

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A25, solute carrier family 22 member 25
Synonyms

HIMTP, UST6
Links

HGNC:32935

NCBI Gene ID: 387601

neXtProt AC: NX_Q6T423

UniProt: Q6T423
Chr Location

11q12.3; chr11:63158437-63243599 (-) GRCh38

Human Ortholog

SLC22A9, solute carrier family 22 member 9
Synonyms

HOAT4, OAT4, OAT7, ust3, UST3H
Links

HGNC:16261

NCBI Gene ID: 114571

neXtProt AC: NX_Q8IVM8

UniProt: Q8IVM8
Chr Location

11q12.3; chr11:63369785-63410294 (+) GRCh38

MGI Vertebrate Homology

Slc22a26 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: SLC22A25, SLC22A9
Gene Tree

Slc22a26

Diseases

2 with human SLC22A9 associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome DOID:0112182 OMIM:276300 ORDO:252202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

3
CCDS

CCDS29533.1

Ensembl

ENSMUSG00000053303 (Evidence)
NCBI Gene

236149

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053303	Ensembl Gene Model \| MGI Sequence Detail	21627	C57BL/6J	± kb
transcript	ENSMUST00000065634	Ensembl \| MGI Sequence Detail	2007	Not Applicable
polypeptide	ENSMUSP00000064809	Ensembl \| MGI Sequence Detail	552	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 23

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 3
Earliest

J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Slc22a26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158005	Chr19:7780049-7780055 (-)	-20 bp
Tssr158004	Chr19:7780034-7780045 (-)	-8 bp
Tssr158003	Chr19:7780011-7780031 (-)	11 bp
Tssr158002	Chr19:7779550-7779565 (-)	474 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24