Tg(APPSWE)2576Kha
Transgene Detail

Summary

• Symbol: Tg(APPSWE)2576Kha
• Name: transgene insertion 2576, Karen Hsiao Ashe
• MGI ID: MGI:2385631
• Synonyms: APP695swe, APPK670N,M671L, APPSw, APPswe Tg2576, hAPP, K670N/M671L, Tg2576, Tg(APPSWE)2576HKahs, Tg(APPSWE)2576Kahs, Tg(HuAPP695.K670-M671L)2576, TgN(APPSWE)2576
• Transgene: Tg(APPSWE)2576Kha Location: unknown
• Alliance: Tg(APPSWE)2576Kha page

Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35^{Gt(RRK261)Byg}/Vps35⁺ Tg(APPSWE)2576Kha/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APPSWE)2576Kha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes the Swedish mutation.

• Mutation details: Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. (J:29880, J:80638)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available

References

• Original: J:80638 Hsiao K, et al., Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996 Oct 4;274(5284):99-102
• All: 734 reference(s)