Tg(Ins2-Fasl)24Ach
Transgene Detail

Summary

• Symbol: Tg(Ins2-Fasl)24Ach
• Name: transgene insertion 24, Alexander V Chervonsky
• MGI ID: MGI:2385760
• Synonyms: RIP-FasL, Tg(Ins2-Tnfsf6)24Ach, TgN(RIP-Tnfsf6)24Ach
• Transgene: Tg(Ins2-Fasl)24Ach Location: unknown
• Alliance: Tg(Ins2-Fasl)24Ach page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Fasl)24Ach expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fasl (MGI:99255)

• Tg(Ins2-Fasl)24Ach expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgene expresses Fas ligand under the control of a rat insulin promoter, which is active in beta cells of the pancreas. (J:78679)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78679 Chervonsky AV, et al., The role of Fas in autoimmune diabetes. Cell. 1997 Apr 4;89(1):17-24
• All: 2 reference(s)