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Bcas3 Gene Detail
Summary
  • Symbol
    Bcas3
  • Name
    BCAS3 microtubule associated cell migration factor
  • Synonyms
    1500019F07Rik, 2610028P08Rik, breast carcinoma amplified sequence 3, K20D4, Phaf2, rudhira
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385848
    NCBI Gene: 192197
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:85243993-85716884 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385848
 protein coding gene Chr11:85243611-85716884 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018882
 protein coding gene Chr11:86855449-87357324 (+)
A/J MGP_AJ_G0018849
 protein coding gene Chr11:83523396-83998967 (+)
AKR/J MGP_AKRJ_G0018819
 protein coding gene Chr11:86023011-86513576 (+)
BALB/cJ MGP_BALBcJ_G0018822
 protein coding gene Chr11:83907280-84382804 (+)
C3H/HeJ MGP_C3HHeJ_G0018636
 protein coding gene Chr11:86051389-86537520 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019274
 protein coding gene Chr11:89497209-90009220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016907
 protein coding gene Chr11:80569812-81039891 (+)
CAST/EiJ MGP_CASTEiJ_G0018191
 protein coding gene Chr11:86699671-87193817 (+)
CBA/J MGP_CBAJ_G0018607
 protein coding gene Chr11:93298219-93803656 (+)
DBA/2J MGP_DBA2J_G0018715
 protein coding gene Chr11:83096350-83571816 (+)
FVB/NJ MGP_FVBNJ_G0018704
 protein coding gene Chr11:82596605-83071003 (+)
LP/J MGP_LPJ_G0018785
 protein coding gene Chr11:87364428-87852927 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018731
 protein coding gene Chr11:93420192-93923727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019314
 protein coding gene Chr11:86268542-86756037 (+)
PWK/PhJ MGP_PWKPhJ_G0017960
 protein coding gene Chr11:83871831-84354376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017752
 protein coding gene Chr11:85819676-86299998 (+)
WSB/EiJ MGP_WSBEiJ_G0018242
 protein coding gene Chr11:86119695-86609654 (+)



Homology
more
  • Human Ortholog
    BCAS3, BCAS3 microtubule associated cell migration factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCAS3, BCAS3 microtubule associated cell migration factor
  • Synonyms
    GAOB1, HEMARS, MAAB, PHAF2
  • Links
    NCBI Gene ID: 54828
    neXtProt AC: NX_Q9H6U6
    UniProt: Q9H6U6

  • Chr Location
    17q23.2
Human Diseases
more
  • Diseases
    1 with human BCAS3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a conditional allele activated in endothelial cells exhibit embryonic lethality with abnormal development and cardiovascular patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    42
  • cDNA Data
    97
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059439 Ensembl Gene Model | MGI Sequence Detail 472892 C57BL/6J ±  kb
    transcript ENSMUST00000108061 Ensembl | MGI Sequence Detail 3810 Not Applicable  
    polypeptide ENSMUSP00000103696 Ensembl | MGI Sequence Detail 943 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000004680 BCAS3 microtubule associated cell migration factor
      (term hierarchy)
    • InterPro Domains
      IPR022175 BCAS3 domain
      IPR045142 BCAS3-like
      IPR048382 BCAS3, WD40 domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q8CCN5 5 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 97
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917451, MGI:1923594, MGI:2144406
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262744 Shetty R, et al., Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory