Tifab MGI Mouse Gene Detail - MGI:2385852 - TRAF-interacting protein with forkhead-associated domain, family member B

Symbol

Tifab
Name

TRAF-interacting protein with forkhead-associated domain, family member B
Synonyms

MGC:32345, MGC:37193

Feature Type

protein coding gene
IDs

MGI:2385852
NCBI Gene: 212937
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr13:56321517-56326698 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

2 experiments

SNPs within 2kb

315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385852	protein coding gene	Chr13:56318917-56326816 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020614	protein coding gene	Chr13:55703942-55709082 (-)
A/J	MGP_AJ_G0020568	protein coding gene	Chr13:53638529-53643695 (-)
AKR/J	MGP_AKRJ_G0020546	protein coding gene	Chr13:55228313-55233495 (-)
BALB/cJ	MGP_BALBcJ_G0020564	protein coding gene	Chr13:53870635-53875800 (-)
C3H/HeJ	MGP_C3HHeJ_G0020363	protein coding gene	Chr13:55036004-55041166 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020998	protein coding gene	Chr13:57397488-57402674 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018580	protein coding gene	Chr13:51571842-51577236 (-)
CAST/EiJ	MGP_CASTEiJ_G0019877	protein coding gene	Chr13:55149125-55154238 (-)
CBA/J	MGP_CBAJ_G0020323	protein coding gene	Chr13:59592699-59597861 (-)
DBA/2J	MGP_DBA2J_G0020446	protein coding gene	Chr13:53187720-53192902 (-)
FVB/NJ	MGP_FVBNJ_G0020425	protein coding gene	Chr13:52653814-52658997 (-)
LP/J	MGP_LPJ_G0020522	protein coding gene	Chr13:55961528-55966709 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020454	protein coding gene	Chr13:59010858-59016039 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021041	protein coding gene	Chr13:54811878-54817060 (-)
PWK/PhJ	MGP_PWKPhJ_G0019633	protein coding gene	Chr13:53216594-53221824 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019460	protein coding gene	Chr13:53743321-53748463 (-)
WSB/EiJ	MGP_WSBEiJ_G0019939	protein coding gene	Chr13:55176629-55181791 (-)

Human Ortholog

TIFAB, TIFA inhibitor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIFAB, TIFA inhibitor
Links

HGNC:34024

NCBI Gene ID: 497189

neXtProt AC: NX_Q6ZNK6

UniProt: Q6ZNK6
Chr Location

5q31.1; chr5:135444226-135452351 (-) GRCh38

MGI Vertebrate Homology

Tifab stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TIFAB
Gene Tree

Tifab

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Tifab
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit progressive hematopoietic defects, including skewed hematopoietic stem/progenitor cell proportions, altered myeloid differentiation, a bone marrow failure-like disease associated with bone marrow dysplasia and cytopenia, and premature death.

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All GO Annotations

44
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

6
UniProt

1
CCDS

CCDS26558.1

Ensembl

ENSMUSG00000049625 (Evidence)
NCBI Gene

212937

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049625	Ensembl Gene Model \| MGI Sequence Detail	5182	C57BL/6J	± kb
transcript	ENSMUST00000169652	Ensembl \| MGI Sequence Detail	3349	Not Applicable
polypeptide	ENSMUSP00000131162	Ensembl \| MGI Sequence Detail	147	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003287 TRAF-interacting protein with FHA domain-containing protein B

(term hierarchy)
PDB

8WWY
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily

IPR033621 TRAF-interacting protein with FHA domain-containing protein

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All nucleic 18

cDNA 18

Microarray probesets 3

Summaries

All 36

Gene Ontology 5

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tifab:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122770	Chr13:56326858-56326869 (-)	-166 bp
Tssr122769	Chr13:56326800-56326814 (-)	-109 bp
Tssr122768	Chr13:56326744-56326749 (-)	-49 bp
Tssr122767	Chr13:56326677-56326710 (-)	4 bp
Tssr122766	Chr13:56326635-56326646 (-)	57 bp
Tssr122765	Chr13:56326610-56326624 (-)	81 bp
Tssr122764	Chr13:56326464-56326534 (-)	199 bp
Tssr122763	Chr13:56326454-56326461 (-)	240 bp
Tssr122762	Chr13:56326414-56326450 (-)	266 bp
Tssr122761	Chr13:56326395-56326406 (-)	297 bp
Tssr122760	Chr13:56324177-56324199 (-)	2,510 bp
Tssr122759	Chr13:56324077-56324094 (-)	2,612 bp
Tssr122758	Chr13:56323823-56323848 (-)	2,862 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24